Abstract

An application of dimethyl urea and L-tartaric acid as deep eutectic solvent (DES) is demonstrated for the synthesis of 2-(methylamino)-3-nitrospiro[chromene] and N-methyl-3-nitro-4H-chromen-2-amines by a reaction of substituted isatins/pyrazole aldehydes, nucleophiles and (E)-N-methyl-1-(methylthio)-2-nitroethenamine. Systematic studies proved that the dimethyl urea and L-tartaric acid in 2:1 ratio at 80 °C is suitable to give the desired products in good yields in shorter period of reaction time (45 min). This method was extended for water as reaction medium and good yields of the products was obtained in 1 h.

摘要

证明了二甲基尿素和L-酒石酸作为深共熔溶剂（DES）在合成2-（甲基氨基）-3-硝基螺并[ N ] -N-甲基-3-硝基-4 H -chromen -2中的应用。 -胺通过取代的靛红/吡唑醛，亲核试剂和（E）-N-甲基-1-（甲硫基）-2-硝基乙胺的反应而形成。系统研究表明，在80°C下以2：1的比例存在的二甲基脲和L-酒石酸适合在较短的反应时间（45分钟）内以良好的收率获得所需的产物。将该方法扩展到以水为反应介质，并在1小时内获得了良好的产物收率。