Abstract

The primary aims were to (1) identify the factor structure of tests thought to measure semantic and episodic memory and (2) examine whether patterns of impairment would show a double dissociation between these two memory systems at an individual level in patients with temporal lobe epilepsy (TLE). The secondary aim was to explore the impact of epilepsy-related variables on performance. This retrospective study involved a cohort of 54 adults who had been diagnosed with TLE and had undergone a neuropsychological assessment that included four memory tests traditionally used to measure either semantic memory (picture naming, animal fluency) or episodic memory (story recall, word list recall) at a single epilepsy surgery center in Australia. Principal component analysis revealed two factors albeit with unexpected loadings. Picture naming and story recall loaded on one factor. Animal fluency and word list recall loaded on another factor. There was no evidence of a double dissociation between semantic and episodic memory at an individual level. Left hemisphere seizure focus and early age of seizure onset related to worse performance on word list recall, picture naming and animal fluency, respectively. Our study highlights the importance of caution when interpreting the results of neuropsychological assessments, as not all putative tests of semantic and episodic memory may necessarily be measuring the same construct. Future directions for research are also considered.

摘要

主要目的是（1）确定被认为可以测量语义和情景记忆的测试的因子结构，以及（2）检查损伤模式是否会在颞叶癫痫患者的个体水平上显示这两种记忆系统之间的双重分离（TLE）。次要目的是探索癫痫相关变量对表现的影响。这项回顾性研究涉及一组 54 名被诊断患有 TLE 并接受过神经心理学评估的成年人，其中包括四项记忆测试，这些测试传统上用于测量语义记忆（图片命名、动物流畅度）或情景记忆（故事回忆、单词列表回忆） ) 在澳大利亚的一个癫痫手术中心。主成分分析揭示了两个因素，尽管有意想不到的负载。图片命名和故事回忆是一个因素。动物流利度和单词列表回忆加载在另一个因素上。没有证据表明语义记忆和情景记忆在个体层面上存在双重分离。左半球癫痫发作焦点和癫痫发作的早期年龄分别与单词列表回忆、图片命名和动物流畅性的较差表现有关。我们的研究强调了在解释神经心理学评估结果时谨慎的重要性，因为并非所有假定的语义和情景记忆测试都可能必然测量相同的结构。还考虑了未来的研究方向。左半球癫痫发作焦点和癫痫发作的早期年龄分别与单词列表回忆、图片命名和动物流畅性的较差表现有关。我们的研究强调了在解释神经心理学评估结果时谨慎的重要性，因为并非所有假定的语义和情景记忆测试都可能必然测量相同的结构。还考虑了未来的研究方向。左半球癫痫发作焦点和癫痫发作的早期年龄分别与单词列表回忆、图片命名和动物流畅性的较差表现有关。我们的研究强调了在解释神经心理学评估结果时谨慎的重要性，因为并非所有假定的语义和情景记忆测试都可能必然测量相同的结构。还考虑了未来的研究方向。