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Cystic fibrosis-related diabetes and lung disease: an update
European Respiratory Review ( IF 9.0 ) Pub Date : 2021-02-16 , DOI: 10.1183/16000617.0293-2020
Bernadette J Prentice 1, 2 , Adam Jaffe 2, 3 , Shihab Hameed 2, 4, 5 , Charles F Verge 2, 5 , Shafagh Waters 2, 6 , John Widger 2, 3
Affiliation  

The development of cystic fibrosis-related diabetes (CFRD) often leads to poorer outcomes in patients with cystic fibrosis including increases in pulmonary exacerbations, poorer lung function and early mortality. This review highlights the many factors contributing to the clinical decline seen in patients diagnosed with CFRD, highlighting the important role of nutrition, the direct effect of hyperglycaemia on the lungs, the immunomodulatory effects of high glucose levels and the potential role of genetic modifiers in CFRD.



中文翻译:

囊性纤维化相关糖尿病和肺部疾病:更新

囊性纤维化相关糖尿病 (CFRD) 的发展通常会导致囊性纤维化患者的预后较差,包括肺部恶化、肺功能较差和早期死亡率增加。这篇综述强调了导致诊断为 CFRD 的患者出现临床衰退的许多因素,强调了营养的重要作用、高血糖对肺部的直接影响、高血糖水平的免疫调节作用以及遗传修饰剂在 CFRD 中的潜在作用.

更新日期:2021-02-17
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