Partially hydrogenated oils (PHO) have been removed from the food supply due to adverse effects on risk for coronary heart disease (CHD). High‐oleic soybean oils (HOSBO) are alternatives that provide functionality for different food applications. The objective of this study was to determine how consumption of diets containing HOSBO compared to other alternative oils, with similar functional properties, modifies LDL cholesterol (LDLc) and other risk factors and biomarkers of CHD. A triple‐blind, crossover, randomized controlled trial was conducted in humans (n = 60) with four highly‐controlled diets containing (1) HOSBO, (2) 80:20 blend of HOSBO and fully hydrogenated soybean oil (HOSBO+FHSBO), (3) soybean oil (SBO), and (4) 50:50 blend of palm oil and palm kernel oil (PO + PKO). Before and after 29 days of feeding, lipids/lipoproteins, blood pressure, body composition, and markers of inflammation, oxidation, and hemostasis were measured. LDLc, apolipoprotein B (apoB), NonHDL‐cholesterol (HDLc), ratios of total cholesterol (TC)‐to‐HDLc and LDLc‐to‐HDL cholesterol, and LDL particle number and small LDL particles concentration were lower after HOSBO and HOSBO+FHSBO compared to PO (specific comparisons p < 0.05). Other than TC:HDL, there were no differences in lipid/lipoprotein markers when comparing HOSBO+FHSBO with HOSBO. LDLc and apoB were higher after HOSBO compared to SBO (p < 0.05). PO + PKO increased HDLc (p < 0.001) and apolipoprotein AI (p < 0.03) compared to HOSBO and HOSBO+FHSBO. With the exception of lipid hydroperoxides, dietary treatments did not affect other CHD markers. HOSBO, and blends thereof, is a PHO replacement that results in more favorable lipid/lipoprotein profiles compared to PO + PKO (an alternative fat with similar functional properties).

中文翻译：

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与棕榈油混合物相比，食用高油酸大豆油可改善人类的脂质和脂蛋白分布：一项随机对照试验

由于对冠心病 (CHD) 风险产生不利影响，部分氢化油 (PHO) 已从食品供应中剔除。高油酸大豆油 (HOSBO) 是为不同食品应用提供功能的替代品。本研究的目的是确定与具有相似功能特性的其他替代油相比，食用含有 HOSBO 的饮食如何改变低密度脂蛋白胆固醇 (LDLc) 以及其他 CHD 危险因素和生物标志物。在人类 (n = 60) 中进行了一项三盲、交叉、随机对照试验，采用四种高度控制的饮食，其中包含 (1) HOSBO、(2) HOSBO 和完全氢化大豆油的 80:20 混合物 (HOSBO+FHSBO) ，(3) 大豆油 (SBO)，和 (4) 棕榈油和棕榈仁油 50:50 的混合物 (PO + PKO)。在喂养 29 天之前和之后，测量了脂质/脂蛋白、血压、身体成分以及炎症、氧化和止血标志物。HOSBO 和 HOSBO+ 后，LDLc、载脂蛋白 B (apoB)、非 HDL 胆固醇 (HDLc)、总胆固醇 (TC) 与 HDLc 的比率、LDLc 与 HDL 胆固醇的比率以及 LDL 颗粒数和小 LDL 颗粒浓度降低FHSBO 与 PO 相比（具体比较p  < 0.05）。除 TC:HDL 外，将 HOSBO+FHSBO 与 HOSBO 进行比较时，脂质/脂蛋白标记物没有差异。与 SBO 相比，HOSBO 后 LDLc 和 apoB 较高（p  < 0.05）。 与 HOSBO 和 HOSBO+FHSBO 相比，PO + PKO 增加了 HDLc ( p  < 0.001) 和载脂蛋白 AI ( p < 0.03)。除脂质氢过氧化物外，饮食治疗不影响其他冠心病标志物。HOSBO 及其混合物是 PHO 替代品，与 PO + PKO（具有类似功能特性的替代脂肪）相比，可产生更有利的脂质/脂蛋白分布。