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Ischemia: Nidogen‐1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration (Adv. Sci. 4/2021)
Advanced Science ( IF 14.3 ) Pub Date : 2021-02-17 , DOI: 10.1002/advs.202170016
Aline Zbinden , Shannon L. Layland , Max Urbanczyk , Daniel A. Carvajal Berrio , Julia Marzi , Monika Zauner , Anne Hammerschmidt , Eva M. Brauchle , Katrin Sudrow , Simon Fink , Markus Templin , Simone Liebscher , Gerd Klein , Arjun Deb , Garry P. Duffy , Gay M. Crooks , Johannes A. Eble , Hanna K. A. Mikkola , Ali Nsair , Martina Seifert , Katja Schenke‐Layland

In article number 2002500 by Katja Schenke‐Layland and co‐workers, the basement membrane protein Nidogen‐1 is shown to promote tissue survival and regeneration in ischemic conditions. Once thought as a simple linker protein, Nidogen‐1 increases heart function and decreases scaring in a myocardial infarction model, rescues pancreatic beta‐cell function in hypoxia, and modulates the immune system, demonstrating the multifaceted effect of Nidogen‐1.
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中文翻译:

缺血:Nidogen-1减轻缺血并促进组织存活和再生(Adv。Sci。4/2021)

在Katja Schenke-Layland及其同事的文章编号2002500中,基底膜蛋白Nidogen-1被证明可促进组织在缺血条件下的存活和再生。曾经被认为是简单连接蛋白的Nidogen-1在心肌梗塞模型中增强了心脏功能并减少了惊吓,在缺氧状态下恢复了胰腺β细胞功能,并调节了免疫系统,证明了Nidogen-1的多方面作用。
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更新日期:2021-02-17
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