Anorexia nervosa (AN) is associated with significant weight loss; thus, it is crucial to discern the contribution of hormones produced by adipose tissue. Some of the adipokines have not been sufficiently studied. Therefore, the present study aims to measure serum concentrations of omentin and visfatin, in adolescent inpatients with AN. The correlations between selected adipokines and psychopathological symptoms of AN were also analyzed.

Thirty adolescent inpatients with anorexia nervosa and thirty healthy age and height matched girls (CONT) were enrolled in the study. The physical and mental examination, anthropometric and psychometric assessment - Beck Depression Inventory (BDI), Hamilton Depression Rating Scale (HDRS), Eating Attitude Test (EAT-26) and Yale-Brown Obsessive-Compulsive Scale (YBOCS), and blood analysis were performed at two-time points – in the malnourished patients (AN T1) and after partial weight recovery (8.30 ± 3.75 weeks) (AN T2).

The omentin concentration was not significantly different from the CONT neither in AN T1 nor AN T2. The visfatin level was altered in AN T1 and did not change after partial weight normalization (AN T2). A positive correlation between visfatin and YBOCS was found in AN T2.

Visfatin concentrations were decreased in adolescent inpatients suffering from AN in the acute phase of the disease and did not normalize after partial weight restoration. The studies considering visfatin as a biomarker of the acute phase of AN should be continued. Moreover, the visfatin showed association with the obsessive and compulsive symptoms; thus its participation in non-homeostatic regulation of food intake should be investigated in further studies.

神经性厌食症 (AN) 与显着的体重减轻有关；因此，辨别脂肪组织产生的激素的贡献至关重要。一些脂肪因子尚未得到充分研究。因此，本研究旨在测量青少年 AN 住院患者的 omentin 和 visfatin 的血清浓度。还分析了选定的脂肪因子与 AN 的精神病理学症状之间的相关性。

研究招募了 30 名患有神经性厌食症的青少年住院患者和 30 名年龄和身高匹配的健康女孩 (CONT)。身体和心理检查、人体测量和心理测量评估 - 贝克抑郁量表 (BDI)、汉密尔顿抑郁量表 (HDRS)、饮食态度测试 (EAT-26) 和耶鲁-布朗强迫症量表 (YBOCS) 以及血液分析在两个时间点进行——营养不良患者 (AN T1) 和部分体重恢复后 (8.30 ± 3.75 周) (AN T2)。

无论是在 AN T1 还是 AN T2 中，网膜蛋白浓度都与 CONT 没有显着差异。内脂素水平在 AN T1 中发生了改变，并且在部分体重正常化 (AN T2) 后没有变化。在 AN T2 中发现内脂素和 YBOCS 之间存在正相关。

在急性期患有 AN 的青少年住院患者中，内脂素浓度降低，并且在部分体重恢复后没有恢复正常。应继续将内脂素作为 AN 急性期生物标志物的研究。此外，内脂素与强迫症状有关；因此，应在进一步的研究中调查其参与食物摄入的非稳态调节。