A phytochemical investigation on the twigs and leaves of Melodinus cochinchinensis (Lour.) Merr. resulted in the isolation and identification of 22 compounds, including seven sesamin-type lignans (1–7), three pentacyclic triterpenes (8–10), one anthraquinone (11), one flavanone (12), two phenolic compounds (13 and 14), five aspidosperma-type indole alkaloids (15–19), and three eburnan-type indole alkaloids (20–22). The structures of these compounds were elucidated by means of spectroscopic analysis, including HREIMS together with 1D and 2D NMR experiments, and comparison with reported data. Among them, compounds 1/4, 2/5, and 3/6 are three pairs epimers at C-7''. Compounds 1–6, 8 and 11 were firstly isolated from the family Apocynaceae, whereas 17 was isolated from Melodinus species for the first time. Compound 8 was only found in Juglans hopeiensis, while 11 was only found in roots of Rubia cordifolia. Compounds 1–6, 8, 11 and 15–22 could be considered as chemotaxonomic markers for M. cochinchinensis. Furthermore, the chemotaxonomic significance and distribution of these isolates in Melodinus genus are discussed in detail.

Merodinus cochinchinensis（Lour。）Merr。的嫩枝和叶片的植物化学研究 结果分离并鉴定了22种化合物，包括7种芝麻素型木脂素（1 – 7），3种五环三萜（8 – 10），1种蒽醌（11），1种黄烷酮（12），2种酚类化合物（13和14）），五种精子植物型吲哚生物碱（15 – 19）和三种依本汗型吲哚生物碱（20 – 22））。通过光谱分析，包括HREIMS以及1D和2D NMR实验，阐明了这些化合物的结构，并与报道的数据进行了比较。其中，化合物1 / 4，2/5，和3 / 6在C-7 ''三个差向异构体。化合物1 - 6，8和11被首先从夹竹桃科分离，而17是从分离山橙属物种首次。化合物8仅在希望核桃中发现，而11仅在香根草的根中发现。茜草。化合物1 - 6，8，11和15 - 22可以被认为是用于化学分类标记M.门冬。此外，详细讨论了这些分离株在melodinus属中的化学分类学意义和分布。