Measurement of Health-Related Quality of Life (HRQoL) is emerging as an important clinical endpoint which complements diagnostic workup and contributes to place patients at the centre of the decision-making process through the recognition of their needs, concerns, goals and expectations.

Chronic excessive cortisol exposure in Cushing’s syndrome (CS) causes severe physical and psychological morbidity which invariably affects HRQoL during the active phase of the disease and even after successful treatment. This sustained deterioration of patient’s wellbeing is partly related to the persistence of several features associated with prior cortisol excess, including affective disorders, cognitive dysfunctions and negative illness perception.

The aim of this review is to summarize the most recent evidence on HRQoL in CS, including the main determinants of its impairment and the results of some educational programs specifically addressed to improve patient’s coping abilities. The preliminary results of an unpublished survey on patient’s unmet needs will also be presented.

与健康相关的生活质量（HRQoL）的测量正在作为重要的临床终点出现，它补充了诊断工作，并通过承认患者的需求，关注，目标和期望，使患者成为决策过程的中心。

库欣综合征（CS）中长期过量摄入皮质醇会导致严重的身体和心理疾病，在疾病活跃期甚至成功治疗后，都会不可避免地影响HRQoL。患者健康状况的这种持续恶化部分与先前皮质醇过量相关的若干特征的持续存在有关，包括情感障碍，认知功能障碍和疾病消极感。

这篇综述的目的是总结关于CS中HRQoL的最新证据，包括其受损的主要决定因素以及一些专门针对提高患者应对能力的教育计划的结果。还将发表关于患者未满足需求的未发表调查的初步结果。