JBIC Journal of Biological Inorganic Chemistry ( IF 2.7 ) Pub Date : 2021-02-17 , DOI: 10.1007/s00775-021-01849-9 Melanie Paul 1 , Alexander Hoffmann 1 , Sonja Herres-Pawlis 1
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Inspired by the efficiency of natural enzymes in organic transformation reactions, the development of synthetic catalysts for oxygenation and oxidation reactions under mild conditions still remains challenging. Tyrosinases serve as archetype when it comes to hydroxylation reactions involving molecular oxygen. We herein present new copper(I) guanidine halide complexes, capable of the activation of molecular oxygen at room temperature. The formation of the reactive bis(µ-oxido) dicopper(III) species and the influence of the anion are investigated by UV/Vis spectroscopy, mass spectrometry, and density functional theory. We highlight the catalytic hydroxylation activity towards diverse polycyclic aromatic alcohols under mild reaction conditions. The selective formation of reactive quinones provides a promising tool to design phenazine derivatives for medical applications.
Graphic abstract
中文翻译：
室温稳定的多才多艺：氧化反应中高反应性和多功能的铜胍配合物
受有机转化反应中天然酶效率的启发，开发在温和条件下进行氧化和氧化反应的合成催化剂仍然具有挑战性。当涉及分子氧的羟基化反应时，酪氨酸酶充当原型。我们在此提出了新型铜（I）胍卤化物配合物，能够在室温下活化分子氧。通过紫外/可见光谱、质谱和密度泛函理论研究了活性双（μ-氧化）二铜（III）物质的形成以及阴离子的影响。我们重点介绍了在温和反应条件下对多种多环芳香醇的催化羟基化活性。反应性醌的选择性形成为设计医疗应用吩嗪衍生物提供了一种有前途的工具。
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