In this study, the authors report the synthesis of a new Mannich base formed by the condensation of pyrrole (C₄H₅N), 4-hydroxybenzaldehyde (C₇H₆O₂) and phthalimide (C₈H₅NO₂) and the respective copper (II) (Cu²⁺), nickel (II) (Ni²⁺) and cobalt (II) (Co²⁺) transition metal complexes derived from the ligand. The synthesized ligand and the metal complexes were characterized using elemental analysis, electrical conductivity studies and spectral studies. The geometry of the Mannich base metal (II) complexes was studied by ultraviolet–visible and electron spin resonance spectroscopy, and all the complexes were found to adopt square planar geometry. Among all the complexes, the cobalt complex was observed to show better antioxidant properties. It is noteworthy to mention that the copper complex is observed to exhibit better deoxyribonucleic acid cleavage activity at all concentrations compared with other complexes.

中文翻译：

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基于曼尼希碱配体的过渡金属（II）配合物的抗菌活性

在这项研究中，作者报告了由吡咯（C ₄ H ₅ N），4-羟基苯甲醛（C ₇ H ₆ O ₂）和邻苯二甲酰亚胺（C ₈ H ₅ NO ₂）缩合形成的新曼尼希碱的合成。分别为铜（II）（Cu ²⁺），镍（II）（Ni ²⁺）和钴（II）（Co ²⁺）衍生自配体的过渡金属络合物。使用元素分析，电导率研究和光谱研究对合成的配体和金属配合物进行了表征。通过紫外可见光谱和电子自旋共振光谱研究了曼尼希贱金属（II）配合物的几何形状，发现所有配合物均采用正方形平面几何形状。在所有配合物中，观察到钴配合物显示出更好的抗氧化性能。值得一提的是，与其他配合物相比，在所有浓度下观察到的铜配合物均表现出更好的脱氧核糖核酸裂解活性。