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HLA Profile of Kami Population Refutes the Earlier Proposition of Exclusive Closer Genetic Affinity of All the Gorkhas to Mongoloids
Human Heredity ( IF 1.8 ) Pub Date : 2021-02-16 , DOI: 10.1159/000514220
Bisu Singh , Dependra Chamlagai , Jiwan Gurung

Objective: Based on the HLA profile of Indian Gorkhas, Debnath and Chaudhuri (2006) proposed that Gorkhas are genetically closer to Mongoloids, and they may have originated from Mongolians or Tibetan stocks. However, the major limitation of the earlier study was that Gorkhas comprise 2 broad groups, i.e. Tibeto-Burmans and Indo-Aryans. Besides, Gorkhas have an assemblage of many sociocultural and linguistically distinct populations such as Rai, Magar, Limbu, Tamang, Newar, Bahun, Kami, and so on. Thus, the generalization of the findings on Gorkhas by considering them as a single homogenous population may not be free from biases. Therefore, the present study aims to understand the genetic affinity of a constituent population from the Gorkha community, i.e. Kami, based on HLA polymorphism. Methods: First field HLA typing was performed among 158 Kami individuals by PCR-SSP methods. Results: The most frequent genes observed were HLA-A*11, HLA-B*15, HLA-DRB1*15. The frequency of HLA-DRB1*15 reported here is the highest recorded among the North Indian population to date, which is a noteworthy finding of the study. The hierarchical cluster analysis and principal component analysis showed that the Kami population lies within the cluster of the Indian subcontinental population. Conclusion: The study refutes the earlier proposition of exclusive belongingness of all the Gorkhas to Mongoloids.
Hum Hered


中文翻译:

Hami人口的HLA资料驳斥了所有Gorkhas与Mongoloids的独家近亲遗传亲和力的早期主张

目的:基于印度戈尔卡人的HLA资料,Debnath和Chaudhuri(2006)提出,戈尔卡人在遗传上更接近蒙古人种,并且可能起源于蒙古族或藏族种群。但是,早期研究的主要局限性在于戈尔卡人包括2个广泛的群体,即藏缅人和印支雅利安人。此外,戈尔卡斯人有许多不同的社会文化和语言群体,例如莱,马加尔,林布,塔曼,纽瓦尔,巴洪,卡米等。因此,将戈尔卡斯族的发现归纳为一个单一的同质种群可能并没有偏见。因此,本研究旨在基于HLA多态性来了解Gorkha社区即Kami的组成人群的遗传亲和力。方法:通过PCR-SSP方法在158位Kami个体中进行了第一场HLA分型。结果:观察到的最常见的基因是HLA-A * 11,HLA-B * 15,HLA-DRB1 * 15。此处报道的HLA-DRB1 * 15的频率是迄今为止北印度人口中记录的最高频率,这是该研究的一个值得注意的发现。层次聚类分析和主成分分析表明,卡米族人口位于印度次大陆人口的聚类之内。结论:这项研究驳斥了所有戈尔喀人对蒙古人独占的主张。
嗡嗡声
更新日期:2021-02-16
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