Abstract

Fluconazole has characteristics that make it widely used in the clinical treatment of C. albicans infections. However, fluconazole has only a fungistatic activity in C. albicans, therefore, in the long-term treatment of C. albicans infection with fluconazole, C. albicans has the potential to acquire fluconazole resistance. A promising approach to increase fluconazole’s efficacy is identifying potential targets of drugs that can enhance the antifungal effect of fluconazole, or even make the drug fungicidal. In this review, we systematically provide a global overview of potential targets of drugs synergistic with fluconazole in C. albicans, identify new avenues for research on fluconazole potentiation, and highlight the promise of combinatorial strategies with fluconazole in combatting C. albicans infections.

摘要

氟康唑的特性使其广泛用于白色念珠菌感染的临床治疗。但是，氟康唑在白色念珠菌中仅具有抑菌活性，因此，在长期用氟康唑治疗白色念珠菌感染中，白色念珠菌具有获得氟康唑抗性的潜力。提高氟康唑疗效的一种有前途的方法是确定可增强氟康唑抗真菌作用甚至使该药具有杀真菌作用的药物的潜在靶标。在这篇综述中，我们系统地提供了白色念珠菌中与氟康唑协同作用的药物的潜在目标的全球概述，确定研究氟康唑增强作用的新途径，并强调与氟康唑结合使用的策略可用于对抗白色念珠菌感染。