The present study examined the influence of selenium on ciprofloxacin‐mediated reproductive dysfunction in rats. The research design consisted of five groups of eight animals each. The rats were administered 135 mg/kg body weight of ciprofloxacin per se or simultaneously with selenium at 0.25 and 0.5 mg/kg for 15 uninterrupted days. Antioxidant and inflammatory indices were assayed using the testes, epididymis, and hypothalamus of the animals after sacrifice. Results revealed that ciprofloxacin treatment per se interfered with the reproductive axis as demonstrated by diminished serum hormonal levels, sperm quality, and enzymatic indices of testicular function, which were, however, abrogated following selenium co‐treatment. Besides this, administration of selenium attenuated the depletion of glutathione level, inhibition of catalase, superoxide dismutase, glutathione‐S‐transferase and glutathione peroxidase activities with a concomitant reduction in reactive oxygen and nitrogen species, and lipid peroxidation in ciprofloxacin‐treated in rats. Selenium treatment also mitigated ciprofloxacin‐mediated elevation in nitric oxide level and of myeloperoxidase activity as well as histological lesions in the animals. Overall, selenium attenuated impairment in the male reproductive axis due to ciprofloxacin treatment through abatement of inflammation and oxidative stress in rats.

中文翻译：

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硒对环丙沙星引起的雄性大鼠下丘脑-垂体-性腺轴功能障碍的缓解

本研究检查了硒对环丙沙星介导的大鼠生殖功能障碍的影响。研究设计包括五组，每组八只动物。给大鼠本身施用环丙沙星的剂量为135 mg / kg环丙沙星或同时以0.25和0.5 mg / kg的硒剂量连续15天。处死后，使用动物的睾丸，附睾和下丘脑测定抗氧化和炎性指数。结果显示，环丙沙星治疗本身会干扰生殖轴，这可通过血清激素水平，精子质量和睾丸功能酶指标的降低来证明，但硒联合治疗后这些指标被废除了。除此之外，硒的施用可以减轻谷胱甘肽水平的降低，过氧化氢酶的抑制，S-转移酶和谷胱甘肽过氧化物酶的活性伴随着活性氧和氮物种的减少，以及环丙沙星治疗的大鼠脂质过氧化。硒处理还减轻了环丙沙星介导的一氧化氮水平和髓过氧化物酶活性以及动物组织学损害的升高。总体而言，由于环丙沙星可减轻大鼠的炎症和氧化应激，硒可减轻雄性生殖轴的损伤。