In realistic environmental scenarios, soil organisms can be exposed to a combination of pharmaceuticals and agriproducts or within different time frames. Therefore, it is necessary to increase knowledge on soil organism susceptibility under a complex mixture exposure scenario. The present study aimed to assess the susceptibility of the collembolan Folsomia candida to copper and dimethoate on a pre-exposure for 3 generations to human pharmaceuticals (fluoxetine and carbamazepine). Carryover effects on reproductive output and survival were observed after a multigenerational pre-exposure to carbamazepine or fluoxetine, considerably increasing the sensitivity of collembolans to both copper and dimethoate. This was more evident for collembolans pre-exposed to the highest concentrations of both pharmaceuticals (40 mg/kg soil), as demonstrated by a significant reduction in the number of juveniles and increased mortality. In addition, pre-exposure to carbamazepine and fluoxetine induced varying effects on subsequent exposure to the same chemical. Although pre-exposure to carbamazepine led to a decrease in collembolan reproduction, even when transferred to a clean medium, fluoxetine induced severe effects but only when collembolans were exposed to other contaminants (i.e., not when transferred to clean soil). The present study highlighted the need to consider carryover effects and possible interactions between pharmaceuticals and other contaminants under simultaneous exposure. Environ Toxicol Chem 2022;41:592–600. © 2021 SETAC

中文翻译：

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多代人接触人类药物后念珠菌对农用化学品的敏感性

在现实的环境情景中，土壤生物可以暴露于药物和农产品的组合中或在不同的时间范围内。因此，有必要增加对复杂混合物暴露情景下土壤生物易感性的认识。本研究旨在评估collembolan Folsomia candida的易感性对铜和乐果进行 3 代人用药物（氟西汀和卡马西平）的预暴露。在多代人预先接触卡马西平或氟西汀后，观察到对生殖产量和存活率的遗留影响，大大增加了跳虫对铜和乐果的敏感性。对于预先暴露于最高浓度的两种药物（40 mg/kg 土壤）的跳虫来说，这一点更为明显，青少年数量显着减少和死亡率增加就证明了这一点。此外，预先接触卡马西平和氟西汀会对随后接触相同化学品产生不同的影响。尽管预先接触卡马西平会导致跳虫的繁殖减少，即使转移到干净的培养基中，氟西汀会引起严重的影响，但只有当跳虫暴露于其他污染物时（即，不会转移到干净的土壤中）。本研究强调需要考虑同时暴露下药物与其他污染物之间的残留效应和可能的相互作用。环境毒物化学2022；41：592–600。© 2021 SETAC