New genetic prognostic biomarkers in primary central nervous system lymphoma (PCNSL),Brain and Behavior

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New genetic prognostic biomarkers in primary central nervous system lymphoma (PCNSL)
Brain and Behavior ( IF 2.6 ) Pub Date : 2021-02-16 , DOI: 10.1002/brb3.2061
Diego Gomes Candido Reis ₁ , Débora Levy ₂ , Luís Alberto de Pádua Covas Lage _{1,

3} , Hebert Fabrício Culler ₁ , Vanderson Rocha _{1,

3,

4,

5} , Sérgio Paulo Bydlowski ₂ , Maria Cláudia Nogueira Zerbini ₆ , Juliana Pereira _{1,

3}

Affiliation

PCNSL is a rare extranodal NHL with poor prognosis. Tumorigenesis has been associated with hyperactivation of BCR downstream and NFkB pathways. We studied the prognosis of the relative expression profile of target genes of NFkB pathway (MYC, BCL2), the essential transcriptional regulator in hematopoiesis LMO2, the checkpoint regulation pathway MGMT, the transcription factor POU2F1, the immune checkpoint gene PDCD1, and the proto‐oncogene and transcriptional repressor gene BCL6 and its proteins in PCNSL.

中文翻译：

原发性中枢神经系统淋巴瘤（PCNSL）的新的遗传预后生物标志物

PCNSL是一种罕见的结外NHL，预后较差。肿瘤发生与下游BCR和NFkB通路的过度激活有关。我们研究了NFkB途径靶基因（MYC，BCL2），造血细胞LMO2必需的转录调节因子，检查点调节途径MGMT，转录因子POU2F1，免疫检查点基因PDCD1和原PCNSL中的癌基因和转录抑制基因BCL6及其蛋白。

更新日期：2021-04-11

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