Advanced computational techniques and mathematical modeling have become more and more important to the study of cardiac electrophysiology. In this review, we provide a brief history of the evolution of cardiomyocyte electrophysiology models and highlight some of the most important ones that had a major impact on our understanding of the electrical activity of the myocardium and associated transmembrane ion fluxes in normal and pathological states. We also present the use of these models in the study of various arrhythmogenesis mechanisms, particularly the integration of experimental pharmacology data into advanced humanized models for in silico proarrhythmogenic risk prediction as an essential component of the Comprehensive in vitro Proarrhythmia Assay (CiPA) drug safety paradigm.

先进的计算技术和数学建模对心脏电生理学的研究变得越来越重要。在这篇综述中，我们简要介绍了心肌细胞电生理学模型的演变，并重点介绍了一些对我们理解正常和病理状态下心肌电活动和相关跨膜离子通量产生重大影响的最重要的模型。我们还介绍了这些模型在各种心律失常发生机制研究中的应用，特别是将实验药理学数据整合到先进的人性化模型中，用于在 silico致心律失常风险预测中作为综合体外致心律失常检测 (CiPA) 药物安全范式的重要组成部分.