In this work, we used a simple method to construct Janus-shaped TiO_2-x&mSiO₂ nanoparticles composed of gray-black titanium dioxide (TiO_2-x) and mesoporous silica (mSiO₂) serving as carriers to improve the microwave-controlled release performance. In the composite materials, on one hand, the rod-shaped mSiO₂ could realize high-efficiency drug loading, on the other hand, spherical TiO_2-x featuring oxygen vacancy acted as the main microwave absorber. The overall spatial separation between titanium dioxide and silicon dioxide was crucial to enhance microwave conversion efficiency. The Janus-liked nanomaterial was made up of TiO_2-x nanosphere with a diameter of approximately 180 nm on one end and rod-shaped mesoporous silica with about 220 nm in length and 100 nm in diameter on the other end, and the specific surface area of the entire material was 203.25 m²/g. Meanwhile, the cumulative doxorubicin hydrochloride (DOX) loading rate of the carrier reached up to 38 wt% after 24 h. The loading process of the DOX was exothermic, and the noncovalent interaction between the DOX and Janus TiO_2-x&mSiO₂ carrier was mainly van der Waals force. Furthermore, the rates of drug release at 24 h were up to 61 wt%, 69 wt% and 89 wt% at pH 7.0, 5.0 and 3.0, respectively. After microwave stimulation at pH 7.0, the rate of drug release increased observably from 61% to 88% compared to that of non-microwave irradiation. The order of the microwave thermal conversion capability of the samples was Janus TiO_2-x&mSiO₂ > Janus TiO₂&mSiO₂ > core-shell TiO_2-x@mSiO₂. Besides, cytotoxicity tests indicated that Janus TiO_2-x&mSiO₂ nanoparticles had good biocompatibility. Therefore, the multifunctional carrier of the Janus-shaped configuration could not only release drugs under pH control, but also be further triggered by microwave stimulation. The Janus-shaped TiO_2-x&mSiO₂ nanoparticles will look forward to laying foundation to the application in drug delivery systems.

在这项工作中，我们使用一种简单的方法来构造由灰黑色二氧化钛（TiO _{2- x}）和中孔二氧化硅（m SiO ₂）组成的Janus形TiO _{2- x}和m SiO ₂纳米颗粒，以改善载体的结构。微波控制释放性能。在复合材料中，一方面，棒状的m SiO ₂可以实现高效的载药量；另一方面，球形的TiO _{2- x}具有氧空位的特征是主要的微波吸收器。二氧化钛和二氧化硅之间的整体空间分隔对于提高微波转换效率至关重要。类似于Janus的纳米材料由一端为约180nm的TiO _{2- x}纳米球和另一端为长约220nm，另一端为直径100nm的棒状介孔二氧化硅构成。整个材料的面积为203.25m ² / g。同时，载体的累积盐酸阿霉素（DOX）负载率在24小时后达到38 wt％。DOX的加载过程是放热的，并且DOX与Janus TiO _{2- x}和m SiO之间的非共价相互作用_2号航母主要是范德华力。此外，在pH 7.0、5.0和3.0时，24 h的药物释放速率分别高达61 wt％，69 wt％和89 wt％。在pH 7.0的微波刺激下，与非微波辐照相比，药物释放速率从61％明显提高到88％。样品的微波热转化能力的顺序为Janus TiO _{2- x}＆m SiO ₂  > Janus TiO ₂＆m SiO ₂  >核-壳TiO ₂ - _x @ m SiO ₂。此外，细胞毒性测试表明Janus TiO _{2- x}＆mSiO ₂纳米粒子具有良好的生物相容性。因此，Janus形结构的多功能载体不仅可以在pH值控制下释放药物，还可以通过微波刺激进一步触发。Janus形的TiO ₂ - _x和m SiO ₂纳米粒子将为在药物输送系统中的应用奠定基础。