Aphemia with pure word dumbness is a relatively rare clinical syndrome caused by injury to the Broca area of the dominant hemisphere. Patients with this syndrome have significant difficulties in oral expression, whereas other language functions, such as written expression and comprehension, are normal. In this study, a patient without no evidence of structural brain lesions presented with aphemia with pure word dumbness after head trauma of the frontal lobe. Through magnetic resonance imaging (MRI) examinations, functional abnormalities (regional homogeneity, degree centrality, and language network) were found in the patient without structural alterations. After four weeks of treatment with repetitive transcranial magnetic stimulation (rTMS) and cognitive evaluation every week, we found that the patient's linguistic function (i.e., spontaneous speech, speech comprehension, rehearsal, naming, reading, writing and the aphasia quotient) recovered gradually. Therefore, rTMS may be an adjuvant therapy for the recovery of aphemia patients with pure word dumbness.

带有纯词哑音的贫血是一种相对罕见的临床综合征，由占优势半球的Broca区域受到损伤而引起。患有这种综合征的患者在口头表达上有很大的困难，而其他语言功能（如书面表达和理解能力）是正常的。在这项研究中，没有任何结构性脑损伤迹象的患者出现额叶头部外伤后出现纯词沉默的贫血。通过磁共振成像（MRI）检查，发现患者的功能异常（区域同质性，程度中心性和语言网络）无结构改变。经过每周四次重复经颅磁刺激（rTMS）治疗和认知评估，我们发现患者的语言功能（即 自发性言语，言语理解，彩排，命名，阅读，写作和失语症患者）逐渐恢复。因此，rTMS可能是恢复纯词性哑语性贫血患者的辅助疗法。