Clozapine is the only medication with Food and Drug Administration approval for treatment-resistant schizophrenia. However, it is underutilized in the United States because of several life-threatening adverse effects, including clozapine-associated myocarditis (CAM), and a limited understanding of how to manage these complications. To date, recommendations for rechallenging patients with CAM that incorporate the cardiac literature or cardioprotective medications have not been developed.

中文翻译：

---

氯氮平相关性心肌炎：监测氯氮平开始使用的方案和如何进行氯氮平再治疗的建议。

氯氮平是唯一获得食品和药物管理局批准用于治疗抵抗性精神分裂症的药物。然而，由于几种危及生命的不良反应，包括氯氮平相关心肌炎 (CAM)，以及对如何处理这些并发症的了解有限，它在美国并未得到充分利用。迄今为止，尚未制定结合心脏文献或心脏保护药物对 CAM 患者进行再挑战的建议。