During the past decades, photo-crosslinked gelatin hydrogel (methacrylated gelatin, GelMA) has gained a lot of attention due to its remarkable application in the biomedical field. It has been widely used in cell transplantation, cell culture and drug delivery, based on its crosslinking to form hydrogels with tunable mechanical properties and excellent bio-compatibility when exposed to light irradiation to mimic the micro-environment of native extracellular matrix (ECM). Because of its unique biofunctionality and mechanical tenability, it has also been widely applied in the repair and regeneration of bone, heart, cornea, epidermal tissue, cartilage, vascular, peripheral nerve, oral mucosa, and skeletal muscle et al. The purpose of this review is to summarize the recent application of GelMA in drug delivery and tissue engineering field. Moreover, this review article will briefly introduce both the development of GelMA and the characterization of GelMA. Finally, we discuss the challenges and future development prospects of GelMA as a tissue engineering material and drug or gene delivery carrier, hoping to contribute to accelerating the development of GelMA in the biomedical field.

中文翻译：

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光交联明胶水凝胶的生物医学应用

在过去的几十年中，光交联的明胶水凝胶（甲基丙烯酸明胶，GelMA）由于在生物医学领域的卓越应用而备受关注。由于其交联形成具有可调节的机械性能和出色的生物相容性的水凝胶，当暴露于光照射以模仿天然细胞外基质（ECM）的微环境时，它已被广泛用于细胞移植，细胞培养和药物传递。由于其独特的生物功能和机械韧性，它还被广泛应用于骨，心脏，角膜，表皮组织，软骨，血管，周围神经，口腔粘膜和骨骼肌等的修复和再生。这篇综述的目的是总结GelMA在药物输送和组织工程领域的最新应用。而且，本文将简要介绍GelMA的开发和GelMA的表征。最后，我们讨论了作为组织工程材料和药物或基因递送载体的GelMA的挑战和未来的发展前景，希望为促进GelMA在生物医学领域的发展做出贡献。