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Highly Stretchable, Tough, Resilient, and Antifatigue Hydrogels Based on Multiple Hydrogen Bonding Interactions Formed by Phenylalanine Derivatives
Biomacromolecules ( IF 5.5 ) Pub Date : 2021-02-12 , DOI: 10.1021/acs.biomac.0c01788 Jing Yu 1 , Kai Xu 1 , Xiaojing Chen 1 , Xiaodan Zhao 2 , Yuxuan Yang 2 , Dake Chu 3 , Yongliang Xu 4 , Qiang Zhang 1 , Yanfeng Zhang 1 , Yilong Cheng 1
Biomacromolecules ( IF 5.5 ) Pub Date : 2021-02-12 , DOI: 10.1021/acs.biomac.0c01788 Jing Yu 1 , Kai Xu 1 , Xiaojing Chen 1 , Xiaodan Zhao 2 , Yuxuan Yang 2 , Dake Chu 3 , Yongliang Xu 4 , Qiang Zhang 1 , Yanfeng Zhang 1 , Yilong Cheng 1
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Noncovalent cross-linked hydrogels with promising mechanical properties are on demand for applications in tissue engineering, flexible electronics, and actuators. However, integrating excellent mechanical properties with facile preparation for the design of hydrogen bond cross-linked hydrogels is still challenging. In this work, an advanced hydrogel was prepared from acrylamide and N-acryloyl phenylalanine by one-pot free-radical copolymerization. Owing to hydrophobicity-assisted multiple hydrogen bonding interactions among phenylalanine derivatives, the hydrogels exhibited fascinating mechanical behaviors: tensile strength of 0.35 MPa, elongation at break of 2100%, tearing energy of 1134 J/m2, and compression strength of 3.56 MPa. The hydrogels also showed robust elasticity and fatigue resistance, and the compression strength did not show any decline, even after 100 successive cycles, as well as promising self-recovery property. In addition, the cytotoxicity test in vitro proved that the hydrogel showed good biocompatibility with normal human liver cells (LO2 cells). The excellent stretchability, robust elasticity, high toughness, fatigue resistance, and biocompatibility of the hydrogel demonstrated its vast potential in the biomedical field and flexible electronic devices.
中文翻译：
基于苯丙氨酸衍生物形成的多个氢键相互作用的高度可拉伸，坚韧，弹性和抗疲劳水凝胶
具有前景良好的机械性能的非共价交联水凝胶是在组织工程，柔性电子产品和致动器中的应用需求。然而，将优异的机械性能与简便的制备方法相结合来设计氢键交联水凝胶仍然具有挑战性。在这项工作中，通过一锅自由基共聚反应，由丙烯酰胺和N-丙烯酰基苯丙氨酸制备了一种高级水凝胶。由于苯丙氨酸衍生物之间的疏水性辅助的多个氢键相互作用，水凝胶表现出令人着迷的机械性能：抗张强度为0.35 MPa，断裂伸长率为2100％，撕裂能为1134 J / m 2。，抗压强度为3.56 MPa。该水凝胶还显示出强大的弹性和抗疲劳性，甚至在连续100次循环后，压缩强度也没有任何下降，并具有良好的自我恢复性能。此外，体外细胞毒性测试证明水凝胶与正常人肝细胞（LO2细胞）表现出良好的生物相容性。水凝胶出色的可拉伸性，强大的弹性，高韧性，抗疲劳性和生物相容性证明了其在生物医学领域和柔性电子设备中的巨大潜力。
更新日期：2021-03-08
中文翻译：
基于苯丙氨酸衍生物形成的多个氢键相互作用的高度可拉伸，坚韧，弹性和抗疲劳水凝胶
具有前景良好的机械性能的非共价交联水凝胶是在组织工程，柔性电子产品和致动器中的应用需求。然而，将优异的机械性能与简便的制备方法相结合来设计氢键交联水凝胶仍然具有挑战性。在这项工作中，通过一锅自由基共聚反应，由丙烯酰胺和N-丙烯酰基苯丙氨酸制备了一种高级水凝胶。由于苯丙氨酸衍生物之间的疏水性辅助的多个氢键相互作用，水凝胶表现出令人着迷的机械性能：抗张强度为0.35 MPa，断裂伸长率为2100％，撕裂能为1134 J / m 2。，抗压强度为3.56 MPa。该水凝胶还显示出强大的弹性和抗疲劳性，甚至在连续100次循环后，压缩强度也没有任何下降，并具有良好的自我恢复性能。此外，体外细胞毒性测试证明水凝胶与正常人肝细胞（LO2细胞）表现出良好的生物相容性。水凝胶出色的可拉伸性，强大的弹性，高韧性，抗疲劳性和生物相容性证明了其在生物医学领域和柔性电子设备中的巨大潜力。
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