Abstract

Heterocyclic chemistry is the basis of pharmaceutical chemistry and drug discovery, and it is the science of the synthesis of biological and pharmaceutical molecules. Heterocycles scaffolds are a key component in the structure of most drugs, natural products and biologically active molecules. In the 21st century, nanocatalysts have opened up new chapter for preparing many chemical transformations with extremely high activity and selectivity, low energy consumption and long lifetime. In recent times, nanomaterials were widely utilized as catalyst in the synthesis of a library of highly substituted heterocycles. In this review, we present recent developments in the application of nanocatalysts in the synthesis of highly substituted heterocycles.

摘要

杂环化学是药物化学和药物发现的基础，是生物和药物分子合成的科学。杂环支架是大多数药物，天然产物和生物活性分子结构中的关键组成部分。在21世纪，纳米催化剂开辟了新的篇章，用于制备具有极高活性和选择性，低能耗和长寿命的许多化学转化。近年来，在高度取代的杂环文库的合成中，纳米材料被广泛用作催化剂。在这篇综述中，我们介绍了纳米催化剂在高度取代杂环的合成中的最新应用。