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Two new steroidal sapogenins from Rohdea chinensis (synonym Tupistra chinensis) rhizomes and their antifungal activity
Journal of Asian Natural Products Research ( IF 1.3 ) Pub Date : 2021-02-15 , DOI: 10.1080/10286020.2021.1886088
Shu-Feng Yao 1, 2, 3 , Hai-Bo Zhang 1 , Zhao-Sheng Cai 3 , Hong Gao 1 , Dan Wang 1 , Shi-Bin Shang 1, 2
Affiliation  

Abstract

Two novel acylated steroidal sapogenins, 3β-acetoxy-1α, 2α, 4β, 5α, 7α-pentahydroxy-spirost-25(27)-en-6-one (1) and (25S)-3α-acetoxy-1α, 2β, 4α, 5α, 7α-pentahydroxyspirostan-6-one (2), together with two known steroidal sapogenins (3 and 4), were isolated from Rohdea chinensis rhizomes. Their structures were elucidated by nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. In addition, the antifungal activities of the isolated compounds against Penicillium digitatum and Rhizopus stolonifera were evaluated. Compound 2 significantly inhibited R. stolonifera growth, which was comparable to the positive control (sodium benzoate and carbendazim). Compound 4 showed the highest potency to inhibit P. digitatum growth compared to other compounds.



中文翻译:

Rohdea chinensis(同义词 Tupistra chinensis)根茎中两种新的甾体皂苷元及其抗真菌活性

摘要

两种新型酰化甾体皂苷元,3 β -acetoxy-1 α、2 α、4 β、5 α、7 α -pentahydroxy-spirost-25(27)-en-6-one ( 1 ) 和 (25S)-3 α -acetoxy-1 α , 2 β , 4 α , 5 α , 7 α -pentahydroxyspirostan-6-one ( 2 ) 以及两种已知的甾体皂苷元 ( 34 ) 从Rohdea chinensis中分离出来根茎。通过核磁共振 (NMR) 和质谱 (MS) 数据阐明了它们的结构。此外,评估了分离的化合物对指青霉根霉的抗真菌活性。化合物2显着抑制了匍匐茎的生长,这与阳性对照(苯甲酸钠和多菌灵)相当。与其他化合物相比,化合物4显示出抑制P. digitatum生长的最高效力。

更新日期:2021-02-15
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