The study for the development of the nickel-catalyzed highly enantioselective propargylic amination of propargylic carbonates with aniline derivatives is described. The reaction of internal alkyne-substituted propargylic carbonates with a series of aniline derivatives smoothly proceeded in DMSO using a combination of Ni(cod)₂ and (R)-SEGPHOS as the catalyst to give the corresponding chiral propargylic amines in 61–93% yields with 91–97% ee (24 examples).

中文翻译：

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镍催化的苯胺衍生物与丙炔碳酸酯的不对称丙炔化胺化

描述了用苯胺衍生物开发镍催化的炔丙基碳酸酯的高对映选择性炔丙基胺化的研究。内部炔烃取代的炔丙基碳酸酯与一系列苯胺衍生物的反应在DMSO中顺利进行，使用Ni（cod）₂和（R）-SEGPHOS的组合作为催化剂，以61-93％的收率得到相应的手性炔丙基胺ee为91–97％（24个示例）。