Global Evidence of Temperature Acclimation of COVID-19 D614G Linage,Global Challenges

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Global Evidence of Temperature Acclimation of COVID-19 D614G Linage
Global Challenges ( IF 4.4 ) Pub Date : 2021-02-15 , DOI: 10.1002/gch2.202000132
Zhaonian Hao _{1,

2} , Ruyuan Li _{2,

3} , Chengyi Hao ₄ , Haoyuan Zhao ₅ , Xueyan Wan ₁ , Dongsheng Guo ₁

Affiliation

The novel D614G linage is becoming the dominating species of SARS-CoV-2. The impact of meteorological and geographical factors on SARS-CoV-2 pandemic are presently not well understood. This research article presents a retrospective case series. Pandemic and meteorological data from 30 countries and 49 states from USA are collected as of June 10th, 2020. The primary outcome are the coefficients of correlations between meteorological factors and pandemic data. Hierarchical clustering analysis are used on SARS-CoV-2 genome, meteorological factors, and pandemic. Disseminating velocity of SARS-CoV-2 is negatively correlated with average temperature in majority of included countries and states from USA. Proportion of the GR clade is positively associated with temperature, but is negatively correlated with altitude in countries-set. Virus disseminating velocities in states from cluster A (Overwhelming proportion of G + GR + GH clades, GH > 60%) and C (Overwhelming proportion of G + GR + GH clades, G 20–30%) both has negative correlations with temperature, while cluster C has more significant negative correlation than cluster A. Climate and geographical environment are revealed to affect virus spreading. GH and GR clades of SARS-CoV-2 are probably acquiring higher temperature tolerance, while G clade may retain high temperature intolerance.

中文翻译：

COVID-19 D614G 系列温度适应的全球证据

新型 D614G 谱系正在成为 SARS-CoV-2 的主要物种。目前，气象和地理因素对 SARS-CoV-2 大流行的影响尚不清楚。这篇研究文章提出了一个回顾性案例系列。截至2020年6月10日，收集了来自美国30个国家和49个州的流行病和气象数据。主要结果是气象因素与流行病数据之间的相关系数。层次聚类分析用于 SARS-CoV-2 基因组、气象因素和大流行。在美国大多数纳入国家和州，SARS-CoV-2 的传播速度与平均气温呈负相关。 GR分支的比例与温度正相关，但与国家设定的海拔高度负相关。集群 A（G + GR + GH 分支的绝大多数比例，GH > 60%）和 C（G + GR + GH 分支的绝大多数比例，G 20–30%）的病毒传播速度均与温度呈负相关，而C簇比A簇具有更显着的负相关性。气候和地理环境被揭示影响病毒传播。 SARS-CoV-2 的 GH 和 GR 进化枝可能正在获得更高的温度耐受性，而 G 进化枝可能保留高温不耐受性。

更新日期：2021-02-15

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