Children are particularly vulnerable to many classes of the volatile organic compounds (VOCs) detected in indoor environments. The negative health impacts associated with chronic and acute exposures of the VOCs might lead to health issues such as genetic damage, cancer, and disorder of nervous systems. In this study, 40 VOCs including aldehydes and ketones, aliphatic hydrocarbons, esters, aromatic hydrocarbons, cyclic terpenes, alcohols, and glycol ethers were identified and qualified in different locations at the University of Missouri (MU) Child Development Laboratory (CDL) in Columbia, Missouri. Our results suggested that the concentrations of the VOCs varied significantly among classrooms, hallways, and playground. The VOCs emitted from personal care and cleaning products had the highest indoor levels (2-ethylhexanol-1, 3-carene, homomenthyl salicylate with mean concentration of 5.15 µg/m³, 1.57 µg/m³, and 1.47 µg/m³, respectively). A cancer risk assessment was conducted, and none of the 95th percentile dose estimates exceeded the age-specific no significant risk levels (NSRL) in all classrooms. Dimensionless toxicity index scores were calculated for all VOCs using a novel web-based framework called Toxicological Prioritization Index (ToxPi), which integrates multiple sources of toxicity data. According to the method, homomenthyl salicylate, benzothiazole, 2-ethylhexyl salicylate, hexadecane, and tridecane exhibited diverse toxicity profiles and ranked as the five most toxic indoor VOCs. The findings of this study provide critical information for policy makers and early education professionals to mitigate the potentially negative health impacts of indoor VOCs in the childcare facilities.

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日托机构挥发性有机化合物的健康风险评估

儿童特别容易受到在室内环境中检测到的多种挥发性有机化合物 (VOC) 的影响。与 VOC 的慢性和急性暴露相关的负面健康影响可能导致健康问题，例如遗传损伤、癌症和神经系统紊乱。在这项研究中，在哥伦比亚的密苏里大学 (MU) 儿童发展实验室 (CDL) 的不同地点鉴定并鉴定了 40 种 VOC，包括醛和酮、脂肪烃、酯、芳烃、环萜烯、醇和乙二醇醚，密苏里州。我们的结果表明，VOCs 的浓度在教室、走廊和操场之间存在显着差异。个人护理和清洁产品排放的 VOCs 室内水平最高（2-乙基己醇-1、3-蒈烯、3、1.57 µg/m ³和 1.47 µg/ ^{m 3}， 分别）。进行了癌症风险评估，在所有教室中，95% 的剂量估计均未超过特定年龄的无显着风险水平 (NSRL)。使用称为毒理学优先指数 (ToxPi) 的新型基于网络的框架计算所有 VOC 的无量纲毒性指数分数，该框架整合了多个毒性数据来源。根据该方法，水杨酸高薄荷酯、苯并噻唑、水杨酸 2-乙基己酯、十六烷和十三烷表现出不同的毒性特征，并被列为五种毒性最大的室内 VOC。本研究的结果为政策制定者和早期教育专业人士提供了重要信息，以减轻托儿设施中室内挥发性有机化合物对健康的潜在负面影响。