Brain hypoxia has important role to the onset and progression of sporadic form of Alzheimer disease via expression of hypoxia‐inducible factor‐1 (HIF‐1). Crocin by anti‐amyloidogenic property inhibits β‐amyloid formation. However, the molecular mechanism associated with anti‐amyloidogenic activity of crocin is unknown. So, the present study was designed to investigate the effect of crocin on cognitive behavior and expression of HIF‐1α and β‐secretase (BACE1) genes in the brain of neonate rats following different intensities of hypoxia during pregnancy.

中文翻译：

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番红花减轻新生大鼠缺氧不同强度引起的认知障碍和脑分子改变

脑缺氧通过低氧诱导因子-1（HIF-1）的表达对阿尔茨海默病散发形式的发作和进展具有重要作用。番红花具有抗淀粉样蛋白生成特性，可抑制β淀粉样蛋白的形成。但是，与番红花的抗淀粉样活性有关的分子机制尚不清楚。因此，本研究旨在研究番红花对妊娠期不同缺氧强度下新生大鼠大脑认知行为以及HIF-1α和β-分泌酶（BACE1）基因表达的影响。