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The possible impact of socioeconomic, income, and educational status on adverse effects of drug and their therapeutic episodes in patients targeted with a combination of tuberculosis interventions
Saudi Journal of Biological Sciences ( IF 4.4 ) Pub Date : 2021-02-14 , DOI: 10.1016/j.sjbs.2021.02.004
Faisal Imam , Manju Sharma , Naif Obaid Al-Harbi , Mohammad Rashid Khan , Wajhul Qamar , Muzaffar Iqbal , Mohammad Daud Ali , Nemat Ali , Md. Khalid Anwar

First-line antituberculosis (anti-TB) compounds have been considered as proven components of the Directly Observed Treatment-Short course (DOTS). Drug therapy against tuberculosis has been categorized as I, II, or III following the Revised National Tuberculosis Control Program guidelines. Anti-TB are drugs are quite common and show limited adverse effects. However, first-line anti-TB compounds mediated DOTS therapy and were found with several complications. Thus, those drugs have been discontinued. Therefore, the present study was designed to find out the possible impact of socioeconomic, income, and educational status on the adverse effects of drugs and their therapeutic episodes in patients targeted with a combination of tuberculosis intervention. This study found that an increased incidence of tuberculosis was found in patients who have finished high school, contributing to a high percentage of adverse effects. Notably, adverse events were shown maximally in poor patients compared with rich- or high-income patients. On the contrary, a high prevalence of adverse events was shown to be increased in partially skilled workers compared with full-skilled workers. Consequently, adversely considerable events were implicated to be raised in patients associated with minimal socioeconomic class. Such interesting factors would help in monitoring such events in experimental patients.



中文翻译:

社会经济,收入和教育状况对以结核病干预为目标的患者的药物不良反应及其治疗发作的可能影响

一线抗结核(TB)化合物已被视为直接观察到的短程治疗(DOTS)的有效成分。根据修订后的《国家结核病控制计划》指南,针对结核病的药物治疗分为I,II或III类。抗结核药物相当普遍,且不良反应有限。然而,一线抗结核化合物介导了DOTS治疗,并发现了一些并发症。因此,那些药物已经停产。因此,本研究旨在发现社会经济,收入和教育状况对以结核病干预为目标的患者的药物不良反应及其治疗发作的可能影响。这项研究发现,在高中毕业的患者中发现结核病的发病率增加,造成很大比例的不良反应。值得注意的是,与富人或高收入患者相比,贫困患者最大程度地显示了不良事件。相反,与纯技能工人相比,部分技能工人的不良事件发生率更高。因此,暗示与社会经济地位最低的人群相关的患者发生了相当多的不利事件。这些有趣的因素将有助于监视实验患者中的此类事件。与全技能工人相比,部分技能工人的不良事件发生率高。因此,暗示与社会经济地位最低的人群相关的患者发生了相当多的不利事件。这些有趣的因素将有助于监视实验患者中的此类事件。与全技能工人相比,部分技能工人的不良事件发生率高。因此,暗示与社会经济地位最低的人群相关的患者发生了相当多的不利事件。这些有趣的因素将有助于监视实验患者中的此类事件。

更新日期:2021-04-02
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