Background

Hepatocellular carcinoma (HCC) progresses fast and has a poor prognosis, but the growth rate in different TNM stages is not clear. The present study was to estimate the growth rate of HCC with different TNM stages at diagnosis.

Methods

Baseline demographics and tumor characteristics were analyzed for 10145 patients in Surveillance, Epidemiology, and End Results (SEER) Program-registered HCC. Multiple linear regression models were used for age adjustment with patient race, sex, marital status, and HCC grade.

Results

The age at diagnosis was younger in Caucasians and males. The adjusted average age of patients with stage I HCC was 65.26 years. The adjusted age of patients with stage II, IIIA, IIIB, and IIIC was -0.17, -0.25, -0.29, and -0.55 adjusted-year younger compared with patients with stage I HCC (all P < 0.001). The adjusted average age of patients with T1 was 65.26 years. The age adjustment was -0.17, -0.26, and -0.55 respectively (all P < 0.001) for T2, T3 or T4 tumors without distant metastases.

Conclusions

These findings demonstrated that the more advanced the HCC stage at diagnosis, the younger the age at diagnosis and the faster the HCC growth from tumor occurrence.

中文翻译：

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诊断时不同TNM分期肝细胞癌的生长速度不同

背景

肝细胞癌（HCC）进展快，预后差，但不同TNM分期的生长速度尚不清楚。本研究旨在估计诊断时具有不同 TNM 分期的 HCC 的生长速度。

方法

在监测、流行病学和最终结果 (SEER) 计划注册的 HCC 中分析了 10145 名患者的基线人口统计学和肿瘤特征。多元线性回归模型用于根据患者种族、性别、婚姻状况和 HCC 分级进行年龄调整。

结果

白种人和男性的诊断年龄更小。I期HCC患者的调整后平均年龄为65.26岁。与 I 期 HCC 患者相比，II 期、IIIA、IIIB 和 IIIC 期患者的调整后年龄分别为 -0.17、-0.25、-0.29 和 -0.55 岁（均P <  0.001）。T1 患者的调整后平均年龄为 65.26 岁。对于没有远处转移的 T2、T3 或 T4 肿瘤，年龄调整分别为 -0.17、-0.26 和 -0.55（均P <  0.001）。

结论

这些发现表明，诊断时HCC分期越晚，诊断年龄越小，HCC从肿瘤发生中生长得越快。