Using 5-mercapto-1-methyltetrazole as the bridge, a porous (~4 nm) Zn metal–organic frameworks coated cuprous oxide/silica core–shell nanostructure (Cu₂O@SiO₂@ZIF-8) was facilely fabricated. Subsequently, using it as a template, the precisely controlled growth of AgNPs with various sizes (2 nm~29 nm) was achieved. It was found that a strong interaction between AgNPs and ZIF-8 in the Cu₂O@SiO₂@ZIF-8 favored the AgNPs to be uniformly distributed in the Cu₂O@SiO₂@ZIF-8. When more AgNPs were obtained in the cavity of Cu₂O@SiO₂@ZIF-8 with large surface areas (~568.95 m²/g), higher SERS response towards phenol red was resulted in. Moreover, 4 nm AgNPs embedded Cu₂O@SiO₂@ZIF-8 substrate showed a lower limit of detection (5.76 × 10^-12 mol·L^-1) and limit of quantification (1.92 × 10^-12 mol·L^-1), and a higher enhancement factor of 1.7 × 10⁷. Additionally, Raman activity of the Cu₂O@SiO₂@ZIF-8@Ag changed little within 35 days, and also the low concentration of phenol red in actual sample can be detected. Therefore, the Cu₂O@SiO₂@ZIF-8@Ag could be employed as highly sensitive and continuously stable 3D substrate for SERS detection of environmental contaminants.

使用5-巯基-1-甲基四唑作为桥，可以方便地制备多孔（〜4 nm）涂覆有氧化亚铜/二氧化硅核-壳纳米结构（Cu ₂ O @ SiO ₂ @ ZIF-8）的锌金属-有机骨架。随后，以其为模板，可以精确控制各种尺寸（2 nm〜29 nm）的AgNP的生长。结果发现，在的AgNPs和ZIF-8之间的强烈的相互作用在Cu ₂ ö@的SiO ₂ @ ZIF-8青睐的AgNPs均匀地分布于Cu ₂ ö@的SiO ₂ @ ZIF-8。当在具有较大表面积（〜568.95 m ^2）的Cu ₂ O @ SiO ₂ @ ZIF-8腔中获得更多AgNP时/克），朝向酚红更高SERS响应导致了，而且，4周纳米的AgNPs嵌入的Cu ₂ ö@的SiO ₂ @ ZIF-8基材显示检测的下限（5.76×10 ^-12摩尔· ^-1）和定量限（1.92×10 ^-12莫尔^-1），和1.7×10更高的增强因子⁷。另外，Cu ₂ O @ SiO ₂ @ ZIF-8 @ Ag的拉曼活性在35天内变化不大，而且实际样品中酚红的浓度低。因此，Cu ₂ O @ SiO ₂@ ZIF-8 @ Ag可用作高度敏感和连续稳定的3D基材，用于SERS检测环境污染物。