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Effect of Eudragit ® NE 40D on The Properties of Pectin Film-Based Polymer Blends
Journal of Polymers and the Environment ( IF 4.7 ) Pub Date : 2021-02-13 , DOI: 10.1007/s10924-021-02083-9
Yupaporn Sampaopan , Jirapornchai Suksaeree

In this work, pectin was used as the primary polymer component while Eudragit® NE 40D was used as polymer blending for the preparation of the thin films. Glycerin was used as a plasticizer. The samples were prepared by a solvent casting method, and their thickness, physicomechanical properties, and moisture ability were characterized. The ratio of Eudragit® NE 40D to pectin was varied to obtain films with tunable mechanical properties and moisture ability. The appearance of the pectin-based blended films was yellowish and transparent by visual observation, and the thicknesses of the pectin-based blended films were in the range of 102–138 µm. The mechanical property of softness of the pectin-based blended films was measured after blending with Eudragit® NE 40D. Thermal stability of pectin-based blended film was also dependent on the amount of Eudragit® NE 40D added; a broadly endothermic and exothermic transition peak were observed. The amorphous state was found in the pectin-based blended films. The cross-sectional morphology of the pectin-based blended films showed a homogeneous film without pores, cracks, or cavities. The moisture content and moisture uptake of the pectin-based blended films were in the range of 18.89–27.52% and 3.38–6.00%, respectively. Overall, the pectin-based blended films showed good properties and these results indicate that pectin-based blended films can potentially be used to prepare thin films for medical and pharmaceutical applications, including drug delivery film dosage forms.



中文翻译:

Eudragit®NE 40D对果胶薄膜基聚合物共混物性能的影响

在这项工作中,果胶用作主要的聚合物组分而尤特奇® NE 40D被用作用于薄膜的制备聚合物共混。甘油用作增塑剂。通过溶剂浇铸法制备样品,并表征其厚度,物理机械性能和湿气性能。的Eudragit的比率® NE 40D到果胶变化以获得具有可调的机械性能和防潮能力的薄膜。通过肉眼观察,基于果胶的共混膜的外观为淡黄色且透明的,并且基于果胶的共混膜的厚度在102-138μm的范围内。基于果胶共混膜的柔软性的机械性能是用Eudragit混合后测得的®NE 40D。基于果胶共混膜的热稳定性也依赖的Eudragit的量® NE 40D加入; 观察到广泛的吸热和放热转变峰。在基于果胶的混合膜中发现了非晶态。果胶基混合膜的横截面形态显示出均匀的膜,没有孔,裂纹或孔洞。果胶基混合膜的水分含量和吸湿率分别在18.89–27.52%和3.38–6.00%的范围内。总体而言,基于果胶的混合薄膜显示出良好的性能,这些结果表明,基于果胶的混合薄膜可潜在地用于制备医疗和制药应用的薄膜,包括药物递送薄膜剂型。

更新日期:2021-02-15
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