Most adolescents experiment with alcohol, but a smaller percentage advance to heavy alcohol use (AU) and AU disorder (AUD). Understanding for whom and how early risk leads to AUD is of interest to prevention, treatment, and etiology of AUD. Informed by developmental and behavioral neuroscience theory, the current study tested whether temperament (effortful control, surgency, and negative affect), peer AU (multi-reporter), and AU with parents’ permission interacted to distinguish youth who experiment with alcohol from those who escalate to AUD. Community adolescents (N = 765, 53% female) were assessed annually for seven years (M_age = 11.8, range: 10–13 at Year 1; M_age = 18.7; range = 17–20 at year 7). Temperament by early experience interactions were expected to predict amount of AU. Amount of AU was expected to mediate the relationship between the interactions and AUD symptoms (assessed at Years 3 and 7, M_age = 13.8 and 18.7) above and beyond a range of confounds (e.g., problem behavior and parental AU and AUD). Supporting hypotheses, effortful control and surgency interacted with AU with parents’ permission and peer AU, respectively, to predict higher amount of AU (R² = 0.47) and AUD symptoms (R² = 0.03). Results support developmental and behavioral neuroscience theory. High surgency and low effortful control in conjunction with peer AU and AU with parents’ permission were associated with large effects on AU and moderate mediated effects through AU to AUD. AU with parents’ permission was risky at low and high effortful control and protective when peers used alcohol.

大多数青少年尝试饮酒，但一小部分人会进入重度饮酒 (AU) 和 AU 障碍 (AUD)。了解早期风险为谁以及如何导致 AUD 对 AUD 的预防、治疗和病因具有重要意义。在发展和行为神经科学理论的指导下，当前的研究测试了气质（努力控制、冲动和负面影响）、同伴 AU（多报告者）和父母许可的 AU 是否相互作用，以区分尝试酒精的青少年和那些尝试饮酒的青少年。升级为澳元。社区青少年（N = 765，53% 女性）每年接受评估，为期 7 年（M_年龄 = 11.8，范围：第 1 年 10-13 岁；M_年龄 = 18.7; 范围 = 第 7 年的 17-20）。早期经验相互作用的气质预计可以预测 AU 的数量。预计 AU 的数量会调节相互作用与 AUD 症状（在 3 岁和 7 岁时评估，M_年龄 = 13.8 和 18.7）之间的关系，并超出一系列混淆（例如，问题行为和父母 AU 和 AUD）。支持假设、努力控制和突发事件分别在父母许可和同伴 AU 的情况下与 AU 交互，以预测更高数量的 AU (R ²  = 0.47) 和 AUD 症状 (R ² = 0.03)。结果支持发育和行为神经科学理论。与同伴 AU 和父母许可的 AU 相结合的高突发性和低努力控制与对 AU 的大影响和通过 AU 到 AUD 的中度介导影响有关。当同龄人饮酒时，经父母许可的 AU 在低强度和高强度的控制和保护方面存在风险。