This study describes the application of gas chromatography coupled to mass spectrometry (GC-MS) to evaluate the occurrence of 12 CECs—contaminants of emerging concern (bisphenol A, diclofenac, 17β-estradiol, estriol, estrone, 17α-ethinylestradiol, gemfibrozil, ibuprofen, naproxen, 4-nonylphenol, 4-octylphenol, and acetaminophen) in surface waters from Paraopeba River Basin, Minas Gerais State, Brazil. The analytical procedure was validated and applied to 60 surface water samples collected across four sampling campaigns along the upper and middle watershed. Methods for CECs determination involved sample filtration, and solid-phase extraction (SPE) with subsequent derivatization of the target compounds prior to their analysis by GC-MS. The LOQ varied from 3.6 to 14.4 ng/L and extraction recoveries ranged from 46.1 to 107.1% for the lowest spiked concentration level (10 ng/L). The results showed a profile of spatial distribution of compounds, as well as the influence of rainfall. Ibuprofen (1683.9 ng/L), bisphenol (1587.7 ng/L), and naproxen (938.4 ng/L) occurred in higher concentrations during the rainy season, whereas during the dry season, the concentrations of bisphenol (1057.7 ng/L), estriol (991.0 ng/L), and estrone (978.4 ng/L) were highlighted. The risk assessment of human exposure shows that for most contaminants, the concentration is well below the estimated thresholds for chronic toxicity from water intake. However, estradiol and 17α-ethinylestradiol showed concentrations in the same order of magnitude as the guide values estimated for babies.

这项研究描述了气相色谱与质谱（GC-MS）联用的应用，以评估12种CEC的出现-新兴的污染物（双酚A，双氯芬酸，17β-雌二醇，雌三醇，雌酮，17α-乙炔雌二醇，吉非罗齐，布洛芬） ，萘普生，4-壬基苯酚，4-辛基苯酚和对乙酰氨基酚）来自巴西米纳斯吉拉斯州Paraopeba流域的地表水中。验证了该分析程序，并将其应用于沿上，中流域的四个采样活动收集的60个地表水样品。CEC的测定方法包括样品过滤和固相萃取（SPE），然后在通过GC-MS分析目标化合物之前将其衍生化。LOQ从3.6到14.4 ng / L不等，提取回收率从46.1到107不等。最低加标浓度（10 ng / L）为1％。结果显示了化合物的空间分布以及降雨的影响。在雨季，布洛芬（1683.9 ng / L），双酚（1587.7 ng / L）和萘普生（938.4 ng / L）的浓度较高，而在旱季，双酚（1057.7 ng / L）的浓度较高。突出显示了雌三醇（991.0 ng / L）和雌酮（978.4 ng / L）。人体暴露的风险评估表明，对于大多数污染物，其浓度远低于摄入水引起的慢性毒性的估计阈值。但是，雌二醇和17α-炔雌醇的浓度与婴儿的指导值相同。以及降雨的影响。在雨季，布洛芬（1683.9 ng / L），双酚（1587.7 ng / L）和萘普生（938.4 ng / L）的浓度较高，而在旱季，双酚（1057.7 ng / L）的浓度较高。突出显示了雌三醇（991.0 ng / L）和雌酮（978.4 ng / L）。人体暴露的风险评估表明，对于大多数污染物，其浓度远低于摄入水引起的慢性毒性的估计阈值。但是，雌二醇和17α-炔雌醇的浓度与婴儿的指导值相同。以及降雨的影响。在雨季，布洛芬（1683.9 ng / L），双酚（1587.7 ng / L）和萘普生（938.4 ng / L）的浓度较高，而在旱季，双酚（1057.7 ng / L）的浓度较高。突出显示了雌三醇（991.0 ng / L）和雌酮（978.4 ng / L）。人体暴露的风险评估表明，对于大多数污染物，其浓度远低于摄入水引起的慢性毒性的估计阈值。但是，雌二醇和17α-炔雌醇的浓度与婴儿的指导值相同。突出显示了雌三醇（991.0 ng / L）和雌酮（978.4 ng / L）。人体暴露的风险评估表明，对于大多数污染物，其浓度远低于摄入水引起的慢性毒性的估计阈值。但是，雌二醇和17α-炔雌醇的浓度与婴儿的指导值相同。突出显示了雌三醇（991.0 ng / L）和雌酮（978.4 ng / L）。人体暴露的风险评估表明，对于大多数污染物，其浓度远低于摄入水引起的慢性毒性的估计阈值。但是，雌二醇和17α-炔雌醇的浓度与婴儿的指导值相同。