Osteoporosis is a state of bone fragility with reduced skeletal resistance to trauma, and consequently increased risk of fracture. A wide range of conditions, including traditional risk factors, lifestyle choices, diseases and their treatments may contribute to bone fragility. It is therefore not surprising that the multi-morbid patient with chronic kidney disease (CKD) is at a particularly high risk. CKD is associated with reduced bone quantity, as well as impaired bone quality. Bone fragility in CKD is a composite of primary osteoporosis, accumulation of traditional and uremia-related risk factors, assaults brought on by systemic disease, and detrimental effects of drugs. Some risk factors are modifiable and represent potential targets for intervention. This review provides an overview of the heterogeneity of bone fragility in CKD.

骨质疏松症是一种骨脆性状态，骨骼对创伤的抵抗力降低，因此骨折风险增加。包括传统风险因素、生活方式选择、疾病及其治疗在内的多种疾病都可能导致骨骼脆弱。因此，患有慢性肾病 (CKD) 的多病患者处于特别高的风险中也就不足为奇了。CKD 与骨量减少以及骨质量受损有关。CKD 中的骨脆性是原发性骨质疏松症、传统和尿毒症相关危险因素的积累、全身性疾病带来的攻击以及药物的不利影响的复合体。一些风险因素是可以修改的，代表了干预的潜在目标。本综述概述了 CKD 骨脆性的异质性。