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Sonic Commentary Audio Series Volume 28
Leonardo Music Journal Pub Date : 2018-12-01 , DOI: 10.1162/lmj_a_01049
Mihail Iossifov 1 , Tsvetana Ivanova 1 , Juan Parra Cancino 2 , Karin de Fleyt , Brice Soniano , Nicolás Varchausky 2 , Nigel Helyer 3 , Jon Drummond , Felipe Otondo 2 , Rebecca Hackemann 3
Affiliation  

The Music of the Love Hormone – Oxytocin represents the challenge to translate biological form (science) into musical form (art). Using a specially developed methodology, we linked the two sides affecting human emotions: hormones, from the inside (science), and music, from the outside (art). DNA codes the proteins, such as hormones, via four letters (nucleic acids) forming three-letter words (codons). Each codon sets one amino acid from the protein’s structure. We have developed an original algorithm in which each codon of DNA represents a certain note. The length of the note is determined by the time needed for the ribosome (cell organelle, producing proteins) to add the corresponding amino acid to the structure of the protein. In this way, the sequence of musical notes is mapped onto the DNA code, and the threedimensional structure of the protein determines the music tempo. The objective of this investigation is to present the properties and the impact of one of the most important human hormones: oxytocin, a hormone called “the love hormone.” Oxytocin is produced in the brain, in the hypothalamus, and is involved in social recognition, maternal affection, and possibly in the formation of empathy and trust between people. As a result, we generated a complete, extremely provocative musical work. In order to verify the accuracy of the musical interpretation, a neurological test was performed and the neurological impact of the hormone and its music was investigated. The preliminary results of this study are presented in this issue [1]. The developed methodology is innovative and creates bridges between art and science knowledge: Physics, genetics, molecular interactions, human physiology, neurology, biofeedback and neuroaesthetics are correlated with music theory and human perception, aiming to get one step further in the development of a “complete mind.” The Music of the Love Hormone – Oxytocin started as an initiative of Art & Science Research Foundation “Re:” in 2014 in Sofia, Bulgaria, fulfilling the challenge to translate biological form into musical form. It is a result of the collaborative work of a cross-disciplinary research team specially assembled as follows: Tsvetana Ivanova, art and science project director; Rositza Marinova, PhD physics student; Todor Ivanov, physicist and algorithm developer; Leandar Litov, physicist; Agnieshka Deynovitch, biofeedback; Mihail Iossifov, composer and musician; and external experts: Dimitar Kolev, neurologist, and Elena Lilkova, computer simulations and 3D structure of the oxytocin receptor. The composer Mihail Yossifov underwent in-depth scientific training about the genetic structure and principles and corresponding 3D structures and intermolecular behavior of the hormone, from its birth and its transportation to the receptor, along with its neuropsychological properties. After internalizing all this knowledge about the invisible nature of this most important human hormone, he had to translate its structure and development processes reference to the laws of music. The composition follows the precise timing and dynamics of the natural laws revealed by the respective scientific disciplines and integrates them into an original art and science composition.

中文翻译:

索尼克评论音频系列第 28 卷

爱情激素的音乐——催产素代表了将生物形式(科学)转化为音乐形式(艺术)的挑战。我们使用一种专门开发的方法,将影响人类情绪的两个方面联系起来:来自内部的荷尔蒙(科学)和来自外部的音乐(艺术)。DNA 通过四个字母(核酸)形成三个字母的单词(密码子)来编码蛋白质,例如激素。每个密码子从蛋白质的结构中设置一个氨基酸。我们开发了一种原始算法,其中每个 DNA 密码子代表一个特定的音符。音符的长度取决于核糖体(细胞器,产生蛋白质)将相应的氨基酸添加到蛋白质结构中所需的时间。通过这种方式,音符的序列被映射到 DNA 代码上,而蛋白质的三维结构决定了音乐的节奏。这项调查的目的是展示最重要的人类荷尔蒙之一的特性和影响:催产素,一种称为“爱情荷尔蒙”的荷尔蒙。催产素在大脑和下丘脑中产生,参与社会认同、母爱,并可能参与人与人之间的同理心和信任的形成。结果,我们创作了一部完整的、极具煽动性的音乐作品。为了验证音乐解释的准确性,进行了神经学测试,并研究了激素及其音乐对神经学的影响。本研究的初步结果见本期[1]。所开发的方法是创新的,并在艺术和科学知识之间架起了桥梁:遗传学、分子相互作用、人体生理学、神经学、生物反馈和神经美学与音乐理论和人类感知相关,旨在进一步发展“完整的心灵”。爱情荷尔蒙的音乐——催产素始于 2014 年在保加利亚索非亚的艺术与科学研究基金会“Re:”的一项倡议,完成了将生物形式转化为音乐形式的挑战。它是一个跨学科研究团队的合作成果,专门组成如下: Tsvetana Ivanova,艺术和科学项目总监;Rositza Marinova,物理学博士生;Todor Ivanov,物理学家和算法开发者;Leandar Litov,物理学家;Agnieshka Deynovitch,生物反馈;Mihail Iossifov,作曲家和音乐家;和外部专家:神经学家 Dimitar Kolev 和 Elena Lilkova,催产素受体的计算机模拟和 3D 结构。作曲家 Mihail Yossifov 接受了关于激素的遗传结构和原理以及相应的 3D 结构和分子间行为的深入科学培训,从它的诞生和它到受体的运输,以及它的神经心理学特性。在内化了关于这种最重要的人类荷尔蒙的无形本质的所有知识后,他必须将其结构和发展过程转化为音乐定律的参考。作品遵循各个科学学科揭示的自然规律的精确时间和动态,并将它们整合到原始的艺术和科学作品中。作曲家 Mihail Yossifov 接受了关于激素的遗传结构和原理以及相应的 3D 结构和分子间行为的深入科学培训,从它的诞生和它到受体的运输,以及它的神经心理学特性。在内化了关于这种最重要的人类荷尔蒙的无形本质的所有知识后,他必须将其结构和发展过程转化为音乐定律的参考。作品遵循各个科学学科揭示的自然规律的精确时间和动态,并将它们整合到原始的艺术和科学作品中。作曲家 Mihail Yossifov 接受了关于激素的遗传结构和原理以及相应的 3D 结构和分子间行为的深入科学培训,从它的诞生和它到受体的运输,以及它的神经心理学特性。在内化了关于这种最重要的人类荷尔蒙的无形本质的所有知识后,他必须将其结构和发展过程转化为音乐定律的参考。作品遵循各个科学学科揭示的自然规律的精确时间和动态,并将它们整合到原始的艺术和科学作品中。以及它的神经心理学特性。在内化了关于这种最重要的人类荷尔蒙的无形本质的所有知识后,他必须将其结构和发展过程转化为音乐定律的参考。作品遵循各个科学学科揭示的自然规律的精确时间和动态,并将它们整合到原始的艺术和科学作品中。以及它的神经心理学特性。在内化了关于这种最重要的人类荷尔蒙的无形本质的所有知识后,他必须将其结构和发展过程转化为音乐定律的参考。作品遵循各个科学学科揭示的自然规律的精确时间和动态,并将它们整合到原始的艺术和科学作品中。
更新日期:2018-12-01
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