Abstract Survivors of severe brain injury may remain in a decreased state of conscious awareness for an extended period of time. Clinical scales are used to describe levels of consciousness but rely on behavioural responses, precipitating misdiagnosis. We have previously utilized event-related potentials (ERPs) to circumvent reliance on behavioural responses. However, practical implementation barriers limit the clinical utility of ERP assessment at point-of-care (POC). To address this challenge, we developed the Halifax Consciousness Scanner (HCS)—a rapid, semi-automated electroencephalography system. The current study evaluated: (i) HCS feasibility in sub-acute, POC settings nationwide; (ii) ERP P300 responses in patients with acquired brain injury versus healthy controls; and (iii) correlations within and between clinical measures and P300 latencies. We assessed 28 patients with severe, chronic impairments from brain injuries and contrasted the results with healthy control data (n = 100). Correlational analyses examined relationships between P300 latencies and the commonly used clinical scales. P300 latencies were significantly delayed in patients compared to healthy controls (P < 0.05). Clinical assessment scores were significantly inter-correlated and correlated significantly with P300 latencies (P < 0.05). In sub-acute and chronic care settings, the HCS provided a physiological measure of neurocognitive processing at POC for patients with severe acquired brain injury, including those with disorders of consciousness.

中文翻译：

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意识点的护理现场脑损伤评估：便携式HCS脑电评估的大规模部署

摘要严重脑损伤的幸存者可能会长时间处于意识下降状态。临床量表用于描述意识水平，但依赖于行为反应，加剧误诊。我们以前利用事件相关电位（ERP）来规避对行为反应的依赖。但是，实际的实施障碍限制了即时诊断（POC）的ERP评估的临床实用性。为了应对这一挑战，我们开发了Halifax意识扫描仪（HCS）—一种快速，半自动的脑电图系统。当前的研究评估：（i）HCS在全国亚急性POC环境中的可行性；（ii）与健康对照组相比，获得性脑损伤患者的ERP P300反应；（iii）临床措施与P300潜伏期之间以及两者之间的相关性。我们评估了28名因脑损伤而导致的严重，慢性损伤的患者，并将结果与​​健康对照数据（n = 100）进行了对比。相关分析检查了P300潜伏期与常用临床量表之间的关系。与健康对照组相比，患者的P300潜伏期显着延迟（P <0.05）。临床评估得分之间呈显着相关，并且与P300潜伏期显着相关（P <0.05）。在亚急性和慢性护理环境中，HCS为患有严重后天性脑损伤（包括意识障碍的患者）的患者在POC提供了神经认知加工的生理指标。由脑损伤引起的慢性损伤，并将结果与​​健康对照数据进行比较（n = 100）。相关分析检查了P300潜伏期与常用临床量表之间的关系。与健康对照组相比，患者的P300潜伏期显着延迟（P <0.05）。临床评估分数之间呈显着相关，并且与P300潜伏期显着相关（P <0.05）。在亚急性和慢性护理环境中，HCS为患有严重后天性脑损伤（包括意识障碍的患者）的患者在POC提供了神经认知加工的生理指标。由脑损伤引起的慢性损伤，并将结果与​​健康对照数据进行比较（n = 100）。相关分析检查了P300潜伏期与常用临床量表之间的关系。与健康对照组相比，患者的P300潜伏期显着延迟（P <0.05）。临床评估分数之间呈显着相关，并且与P300潜伏期显着相关（P <0.05）。在亚急性和慢性护理环境中，HCS为患有严重后天性脑损伤（包括意识障碍的患者）的患者在POC提供了神经认知加工的生理指标。与健康对照组相比，患者的P300潜伏期显着延迟（P <0.05）。临床评估分数之间呈显着相关，并且与P300潜伏期显着相关（P <0.05）。在亚急性和慢性护理环境中，HCS为患有严重后天性脑损伤（包括意识障碍的患者）的患者在POC提供了神经认知加工的生理指标。与健康对照组相比，患者的P300潜伏期显着延迟（P <0.05）。临床评估分数之间呈显着相关，并且与P300潜伏期显着相关（P <0.05）。在亚急性和慢性护理环境中，HCS为患有严重后天性脑损伤（包括意识障碍的患者）的患者在POC提供了神经认知加工的生理指标。