We currently find ourselves in the midst of a global coronavirus disease 2019 (COVID-19) pandemic, caused by the highly infectious novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we discuss aspects of SARS-CoV-2 biology and pathology and how these might interact with the circadian clock of the host. We further focus on the severe manifestation of the illness, leading to hospitalization in an intensive care unit. The most common severe complications of COVID-19 relate to clock-regulated human physiology. We speculate on how the pandemic might be used to gain insights on the circadian clock but, more importantly, on how knowledge of the circadian clock might be used to mitigate the disease expression and the clinical course of COVID-19.

目前，我们正处于全球 2019 年冠状病毒病 (COVID-19) 大流行之中，该疾病是由高度传染性的新型冠状病毒、严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 引起的。在这里，我们讨论 SARS-CoV-2 生物学和病理学的各个方面，以及它们如何与宿主的生物钟相互作用。我们进一步关注疾病的严重表现，导致住院重症监护室。COVID-19 最常见的严重并发症与生物钟调节的人体生理机能有关。我们推测如何利用大流行来深入了解生物钟，但更重要的是，我们推测如何利用生物钟的知识来减轻疾病的表现和 COVID-19 的临床病程。