Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma,Bioconjugate Chemistry

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Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2021-02-12 , DOI: 10.1021/acs.bioconjchem.0c00671
Mikhail Kondrashov ₁ , Samuel P S Svensson _{2,

3} , Peter Ström ₄ , Andreas Westermark ₁ , Hanna Jacobson-Ingemyr ₁ , Akihiro Takano ₁ , Lenke Tari ₁ , Miklós Tóth ₁ , Minying Cai ₅ , Victor J Hruby ₅ , Magnus Schou _{1,

6}

Affiliation

A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes ¹¹C and ¹⁸F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melanoma tumors. Its applicability was further showcased by subsequent in vitro imaging in cells as well as in vivo imaging in melanoma xenograft mice by fluorescence and positron emission tomography.

中文翻译：

新型 Biarsenical 成像探针在黑色素瘤的荧光和 PET 成像中的多种应用

合成了一种新的荧光双砷肽标记探针，并用放射性同位素¹¹ C 和¹⁸ F 进行标记。通过将这些同位素中的每一种安装到黑色素皮质素 1 受体 (MC1R) 结合肽中，证明了该探针的效用，该肽靶向黑色素瘤肿瘤。随后通过荧光和正电子发射断层扫描在细胞中进行体外成像以及在黑色素瘤异种移植小鼠体内成像，进一步展示了其适用性。

更新日期：2021-03-17

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