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A Mussel-Inspired Antibacterial Hydrogel with High Cell Affinity, Toughness, Self-Healing, and Recycling Properties for Wound Healing
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2021-02-12 , DOI: 10.1021/acssuschemeng.0c06672 Xueyong Deng 1 , Bingxue Huang 1 , Qunhao Wang 1 , Wanlin Wu 1 , Phil Coates 2 , Farshid Sefat 2, 3 , Canhui Lu 1, 4 , Wei Zhang 1, 4 , Ximu Zhang 5
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2021-02-12 , DOI: 10.1021/acssuschemeng.0c06672 Xueyong Deng 1 , Bingxue Huang 1 , Qunhao Wang 1 , Wanlin Wu 1 , Phil Coates 2 , Farshid Sefat 2, 3 , Canhui Lu 1, 4 , Wei Zhang 1, 4 , Ximu Zhang 5
Affiliation
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Antibacterial hydrogels have been intensively studied due to their wide practical potential in wound healing. However, developing an antibacterial hydrogel that is able to integrate with exceptional mechanical properties, cell affinity, and adhesiveness will remain a major challenge. Herein, a novel hydrogel with antibacterial and superior biocompatibility properties was developed using aluminum ions (Al3+) and alginate–dopamine (Alg-DA) chains to cross-link with the copolymer chains of acrylamide and acrylic acid (PAM) via triple dynamic noncovalent interactions, including coordination, electrostatic interaction, and hydrogen bonding. The cationized nanofibrillated cellulose (CATNFC), which was synthesized by the grafting of long-chain quaternary ammonium salts onto nanofibrillated cellulose (NFC), was utilized innovatively in the preparation of antibacterial hydrogels. Meanwhile, alginate-modified dopamine (Alg-DA) was prepared from dopamine (DA) and alginate. Within the hydrogel, the catechol groups of Alg-DA provided a decent fibroblast cell adhesion to the hydrogel. Additionally, the multitype cross-linking structure within the hydrogel rendered the outstanding mechanical properties, self-healing ability, and recycling in pollution-free ways. The antibacterial test in vitro, cell affinity, and wound healing proved that the as-prepared hydrogel was a potential material with all-around performances in both preventing bacterial infection and promoting tissue regeneration during wound healing processes.
中文翻译：
贻贝启发的抗菌水凝胶具有高细胞亲和力，韧性，自我修复和可回收的伤口愈合特性。
由于抗菌水凝胶在伤口愈合中具有广泛的实用潜力，因此已经进行了深入研究。然而，开发一种能够与卓越的机械性能，细胞亲和力和粘附性相结合的抗菌水凝胶仍将是一项重大挑战。本文中，使用铝离子（Al 3+）和藻酸盐-多巴胺（Alg-DA）链通过三重动态非共价相互作用（包括配位，静电相互作用和氢键）与丙烯酰胺和丙烯酸（PAM）的共聚物链交联。通过将长链季铵盐接枝到纳米原纤化纤维素（NFC）上而合成的阳离子化纳米原纤化纤维素（CATNFC）被创新地用于制备抗菌水凝胶。同时，由多巴胺（DA）和藻酸盐制备藻酸盐改性的多巴胺（Alg-DA）。在水凝胶中，Alg-DA的儿茶酚基团提供了良好的成纤维细胞粘附于水凝胶的能力。此外，水凝胶中的多种类型的交联结构还具有出色的机械性能，自修复能力和无污染回收的特点。
更新日期：2021-03-01
中文翻译：
贻贝启发的抗菌水凝胶具有高细胞亲和力，韧性，自我修复和可回收的伤口愈合特性。
由于抗菌水凝胶在伤口愈合中具有广泛的实用潜力，因此已经进行了深入研究。然而，开发一种能够与卓越的机械性能，细胞亲和力和粘附性相结合的抗菌水凝胶仍将是一项重大挑战。本文中，使用铝离子（Al 3+）和藻酸盐-多巴胺（Alg-DA）链通过三重动态非共价相互作用（包括配位，静电相互作用和氢键）与丙烯酰胺和丙烯酸（PAM）的共聚物链交联。通过将长链季铵盐接枝到纳米原纤化纤维素（NFC）上而合成的阳离子化纳米原纤化纤维素（CATNFC）被创新地用于制备抗菌水凝胶。同时，由多巴胺（DA）和藻酸盐制备藻酸盐改性的多巴胺（Alg-DA）。在水凝胶中，Alg-DA的儿茶酚基团提供了良好的成纤维细胞粘附于水凝胶的能力。此外，水凝胶中的多种类型的交联结构还具有出色的机械性能，自修复能力和无污染回收的特点。
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