Abstract

The aim of this paper is to study the clinical features of severe intoxications with thallium salts and developing effective care schemes for the application of potassium hexacyanoferrate (II) and deferasirox for correction of detected disorders. A total of 39 patients diagnosed with severe thallium salt poisoning were examined in two groups. Group I comprised 20 patients with severe thallium salt poisoning, who were prescribed with potassium-iron hexacyanoferrate in a dose of 250 mg/kg/day per os, intravenous potassium infusions, furosemide intravenously in amount of 40 mg three times per, and hemodialysis until the thallium level in the blood dropped below 10 mg/L, lactulose 30 mL two times per day per os. Group II consisted of 19 people with severe thallium salt poisoning, which in addition to the above treatment, received Deferasirox in a dosage of 500 mg two times per day per os. The clinical picture of severe poisoning with thallium salts is characterized by lesions of the gastrointestinal tract, nervous system (central and peripheral), alopecia, heart rhythm disorders, and myocardial ischemia zones. Extension of standard therapy with potassium-iron by adding hexacyanoferrate deferasirox showed better effect on thallium elimination rate and improved functional state of liver and kidneys in patients with severe thallium salt poisoning.

摘要

本文的目的是研究with盐严重中毒的临床特征，并开发有效的护理方案以应用六氰合铁酸钾（II）和地拉罗司来纠正所发现的疾病。两组共检查了39名被诊断患有重度salt盐中毒的患者。第一组包括20例重度salt盐中毒的患者，他们按剂量口服250毫克/千克/天的六氰合铁酸钾铁盐，静脉输注钾，每次40毫克静脉注射速尿3次，并进行血液透析直至血液中al水平每天降至两次，低于10 mg / L，乳果糖30 mL。第二组包括19名重度salt盐中毒者，除了上述治疗外，每天两次口服Deferasirox，剂量为500毫克，每天两次。with盐严重中毒的临床表现是胃肠道，神经系统（中枢和外周），脱发，心律失常和心肌缺血区的损害。在重度salt盐中毒患者中，通过添加铁氰化六氰合铁氰菊酯来扩展钾铁标准疗法对th的清除率具有更好的效果，并改善了肝脏和肾脏的功能状态。