ABSTRACT

Background

The free base and protonated nicotine forms in e-cigarette aerosol have shown different absorption profiles in users. Therefore, it is also important to identify the factors which can affect the ratio of these nicotine forms in the aerosol. Such factors may include nicotine concentrations, flavors, PG:VG ratios, types of nicotine chemical compounds and e-cigarette battery power outputs. The current study attempts to identify such factors using a controlled experiment.

Research designs and methods

The aerosol was generated using validated aerosol generating model. Various factors were tested for their effect on nicotine forms. Additionally, a degradation study of one of the nicotine compounds, nicotine salicylate, was also carried out using mass spectrometry.

Results

The free base nicotine in the aerosol was found to be affected by flavors, battery power output, nicotine compound type and PG:VG ratios. Based on the preliminary mass spectrometry data, degradation of nicotine salicylate was found to be one of the significant factors affecting free base nicotine in aerosol.

Conclusions

Potential factors affecting free base nicotine in e-cigarette aerosol have been identified in this study. These findings would help in understanding the nicotine delivery better and assist for better regulations.

中文翻译：

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影响电子烟气溶胶中游离碱尼古丁产量的潜在因素

摘要

背景

电子烟气雾剂中的游离碱和质子化尼古丁形式在用户中显示出不同的吸收曲线。因此，确定影响这些尼古丁形式在气溶胶中的比例的因素也很重要。这些因素可能包括尼古丁浓度、风味、PG:VG 比率、尼古丁化合物的类型和电子烟电池的功率输出。目前的研究试图通过对照实验来识别这些因素。

研究设计和方法

使用经过验证的气溶胶生成模型生成气溶胶。测试了各种因素对尼古丁形式的影响。此外，还使用质谱法对其中一种尼古丁化合物水杨酸尼古丁进行了降解研究。

结果

发现气溶胶中的游离碱尼古丁受风味、电池功率输出、尼古丁化合物类型和 PG:VG 比率的影响。根据初步质谱数据，发现水杨酸尼古丁的降解是影响气溶胶中游离碱尼古丁的重要因素之一。

结论

本研究确定了影响电子烟气溶胶中游离碱尼古丁的潜在因素。这些发现将有助于更好地了解尼古丁的输送，并有助于制定更好的法规。