ABSTRACT

Chronic Obstructive Pulmonary Disease (COPD) is attributable to household air pollution and is known to increase the Disability Adjusted Life Years (DALYs), morbidity and mortality and women are most susceptible groups for the exposure. In order to understand the global risk among women with COPD due to exposure of household air pollutants, an evidence-based systematic review and meta-analysis was conducted. Meta regression analysis was carried out to identify potential sources of heterogeneity. The summary estimates of the included studies showed higher prevalence of COPD due to biomass fuel exposure in women. Clinical diagnosis has shown more risk of COPD prevalence compared to diagnosis based on spirometer test alone. However, the data between included studies for both clinical and spirometry-based studies showed higher heterogeneity. The present meta-data analysis has shown that household air pollutants may be a factor associated with increased risk of COPD in women.

摘要

慢性阻塞性肺病 (COPD) 可归因于家庭空气污染，并且已知会增加伤残调整生命年 (DALY)、发病率和死亡率，并且女性是最容易受到暴露的人群。为了了解因暴露于家庭空气污染物而导致 COPD 女性的全球风险，进行了基于证据的系统评价和荟萃分析。进行元回归分析以确定异质性的潜在来源。纳入研究的汇总估计显示，由于女性接触生物质燃料，COPD 的患病率较高。与仅基于肺活量计测试的诊断相比，临床诊断显示 COPD 患病率更高。然而，临床和基于肺量计研究的纳入研究之间的数据显示出更高的异质性。