Protein kinase C theta (PKCθ) is expressed in ER‐negative breast cancer and promotes cancer stem cells (CSCs) phenotype. PKCθ gene (PRKCQ) is predicted to be a target for tumor suppressor miR‐203. Herein, we aim to validate this prediction and evaluate the ability of miR‐203 to inhibit migration of breast cancer cell line enriched with CSCs, MDA‐MB‐231, via PRKCQ targeting.

中文翻译：

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miR-203和PKCθ之间的串扰调节乳腺癌干细胞标志物

蛋白激酶 C theta (PKCθ) 在 ER 阴性乳腺癌中表达并促进癌症干细胞 (CSC) 表型。PKCθ 基因（PRKCQ）被预测为肿瘤抑制因子miR-203的靶标。在此，我们旨在验证这一预测并评估miR-203通过PRKCQ靶向抑制富含 CSCs MDA-MB-231 的乳腺癌细胞系迁移的能力。