A novel series of pyrrolidinyl-quinoline based pyrazoline derivatives are synthesised by the reaction of a series of Pyrrolidinyl-quinoline chalcones with hydrazine hydrate using Michael addition reaction conditions under microwave irradiation. All synthesized pyrzolines are screened for their in vitro antimicrobial activity against different bacterial and fungal pathogens. Majority of the synthesized compounds demonstrate moderate to good inhibition zones compared to the standard drugs.

中文翻译：

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一种简单高效的微波辅助合成吡咯烷基-喹啉基吡唑啉衍生物及其抗菌活性

在微波辐射下，通过迈克尔加成反应条件，通过一系列吡咯烷基-喹啉查耳酮与水合肼的反应，合成了一系列新的基于吡咯烷基-喹啉的吡唑啉衍生物。筛选所有合成的吡唑啉类化合物对不同细菌和真菌病原体的体外抗菌活性。与标准药物相比，大多数合成化合物显示出中等至良好的抑制区。