Bioactive materials play a significant role in biomedical engineering for plethora of applications. To date, there is no evident report on the role of sodium precursors in structural changes towards their acceleration in biocompatibility. This study highlights the impact and role of two different sodium precursors (sodium nitrate and sodium hydroxide) on the structural changes and their potential formulations in biomineralization and biocompatibility. Structural characteristics enunciate the significant crystallization of NaCaPO₄, Na₂Ca₂Si₃O₉, and Na_1.8Ca_1.1Si₆O₁₄ phases with pertinent Q² stretching's while using sodium nitrate than sodium hydroxide. XPS spectra authenticate the elevated sodium content while using sodium nitrate as sodium precursor. One-dimensional structures with well faceted morphology and superior alkaline environment preferentially support the biomineralization and bactericidal properties in sodium nitrate-bioglass, was confirmed through structural, morphological, elemental, and antibacterial investigations. Whereas, higher blood and cell-line compatibility with elevated protein adsorption rate is perceived for the bioglass prepared using sodium hydroxide source, and subsequently, higher hemostatic properties are considerably observed with sodium nitrate-bioglass. Higher mechanical stability (ultrasonic measurements) and controlled degradation rate are the stratagems of sodium nitrate to boost the basic criteria of bioactive materials. Hence, it is proposed that sodium nitrate is a highly preferable source to develop bioactive and stable bioglass formulations.

生物活性材料在生物医学工程中的大量应用中发挥着重要作用。迄今为止，尚无关于钠前体在促进其生物相容性的结构变化中的作用的明显报道。这项研究强调了两种不同的钠前体（硝酸钠和氢氧化钠）对结构变化的影响和作用以及它们在生物矿化和生物相容性方面的潜在配方。结构特征表明具有相关Q ²的NaCaPO ₄，Na ₂ Ca ₂ Si ₃ O ₉和Na _1.8 Ca _1.1 Si ₆ O ₁₄相的明显结晶。拉伸的同时使用硝酸钠比氢氧化钠。XPS光谱在使用硝酸钠作为钠前体的同时验证了钠含量的升高。通过结构，形态，元素和抗菌研究证实，具有良好切面形态和优越碱性环境的一维结构优先支持硝酸钠-生物玻璃中的生物矿化和杀菌性能。然而，对于使用氢氧化钠源制备的生物玻璃来说，血液和细胞系的相容性更高，蛋白质吸附速率也更高，随后，使用硝酸钠生物玻璃可观察到更高的止血性能。较高的机械稳定性（超声波测量）和受控的降解速率是硝酸钠的策略，可提高生物活性物质的基本标准。因此，提出硝酸钠是开发生物活性和稳定的生物玻璃制剂的高度优选的来源。