Incorporating bioactive nanofillers and creating porous surfaces are two common strategies used to improve the tissue integration of polyetheretherketone (PEEK) material. However, few studies have reported the combined use of both strategies to modify PEEK. Herein, for the first time, dual nanoparticles of graphene oxide (GO) and hydroxyapatite (HAp) were incorporated into PEEK matrix to obtain ternary composites that were laser machined to create macropores with diameters ranging from 200 μm to 600 μm on the surfaces. The surface morphology and chemistry, mechanical properties, and cellular responses of the composites were investigated. The results show that micropatterned pores with a depth of 50 μm were created on the surfaces of the composites, which do not significantly affect the mechanical properties of the resultant composites. More importantly, the incorporation of GO and HAp significantly improves the cell adhesion and proliferation on the surface of PEEK. Compared to the smooth surface composite, the composites with macroporous surface exhibit markedly enhanced cell viability. The combined use of nanofillers and surface macropores may be a promising way of improving tissue integration of PEEK for bone implants.

掺入生物活性纳米填料并创建多孔表面是用于改善聚醚醚酮（PEEK）材料的组织整合的两种常用策略。然而，很少有研究报道两种策略联合使用来修饰PEEK。在本文中，首次将氧化石墨烯（GO）和羟基磷灰石（HAp）的双重纳米颗粒掺入PEEK基质中，获得三元复合材料，然后对其进行激光加工以在表面上形成直径范围为200μm至600μm的大孔。研究了复合材料的表面形貌，化学，机械性能和细胞响应。结果表明，在复合材料的表面上形成了深度为50μm的微图案孔，这不会显着影响所得复合材料的机械性能。更重要的是，GO和HAp的掺入显着改善了PEEK表面上的细胞粘附和增殖。与光滑表面复合材料相比，具有大孔表面的复合材料具有明显增强的细胞活力。纳米填料和表面大孔的组合使用可能是改善PEEK用于骨植入物的组织整合的有前途的方法。