(R)-[Ru(η⁶-p-MeC₆H₄ⁱPr)Cl₂{Ph₂PNHCH(CH₃)(C₆H₄-4-F)}] (1) and cis-(R,R)-[PtCl₂{Ph₂PNHCH(CH₃)(C₆H₄-4-F)}₂] (2) have been obtained by the reaction of the chiral aminophosphine (R)-Ph₂PNHCH(CH₃)(C₆H₄-4-F) with [{RuCl(μ-Cl)(η⁶-p-MeC₆H₄ⁱPr)}₂] or [PtCl₂(cod)] (cod = cycloocta-1,5-diene). Both complexes were characterized by physico-chemical and spectroscopic methods. Compound 1 was also characterized by X-ray crystallography. The antitumor potential of both compounds was investigated by using the crystal violet antiproliferation assay. Complexes 1 and 2 were found to inhibit the growth of three human cancer cell lines, whereby the Ru complex was considerably more potent than the Pt complex, with IC₅₀ values between 1 and 3 and 12–15 µM, respectively, but still less potent than cisplatin in the same three cell lines.

（- [R ）- [茹（η ⁶ - p -MeC ₆ ħ ₄^我PR）氯₂ {博士₂ PNHCH（CH ₃）（C ₆ H ^ ₄ -4-F）}]（1）和顺式- （R， R）-[PtCl ₂ {Ph ₂ PNHCH（CH ₃）（C ₆ H ₄ -4-F）} ₂ ]（2）通过手性氨基膦（R）-Ph ₂ PNHCH（CH ₃）反应制得。）（碳₆ H ₄-4-F）与[{的RuCl（μ-Cl）的（η ⁶ - p -MeC ₆ ħ ₄^我PR）} ₂ ]或[氯铂酸₂（COD）]（COD =环辛-1,5-二烯）。两种配合物均通过物理化学和光谱法表征。化合物1还通过X射线晶体学表征。通过使用结晶紫抗增殖试验研究了这两种化合物的抗肿瘤潜力。发现复合物1和2抑制了三种人类癌细胞系的生长，因此Ru复合物比Pt复合物更有效，IC ₅₀ 值分别在1至3和12–15 µM之间，但在相同的三个细胞系中，其效价仍低于顺铂。