Microbiota inside the gut plays a vital role in maintaining human health. Microbial dysbiosis is associated with various complications leading to a range of diseases. Epigenetic changes enforced by various environmental and lifestyle factors lead to heritable modifications. These epigenetic modifications include DNA methylation, histone modifications, chromatin remodelling, and ribonucleic acid-based mechanisms. This review summarizes the impacts of environmental factors on the gut microbiome, epigenetic modifications, and their role in cardiovascular diseases.

中文翻译：

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肠道微生物失调的表观遗传调控

肠道内的微生物群在维持人类健康方面起着至关重要的作用。微生物菌群失调与导致一系列疾病的各种并发症有关。由各种环境和生活方式因素强制执行的表观遗传变化导致遗传修饰。这些表观遗传修饰包括 DNA 甲基化、组蛋白修饰、染色质重塑和基于核糖核酸的机制。本综述总结了环境因素对肠道微生物组的影响、表观遗传修饰及其在心血管疾病中的作用。