Hypoparathyroidism (HypoPT) and pseudohypoparathyroidism (PHP) are diseases with abnormal calcium and phosphate homeostasis and low and high PTH levels, respectively. It has been hypothesized that this could dispose to vascular calcifications and thereby perhaps also cardiovascular morbidity. The aim of this study was to assess lower leg arterial calcifications (LLAC) in patients with HypoPT or PHP. Using a cross-sectional design, we measured the LLAC using a high-resolution peripheral quantitative computed tomography (HR-pQCT) scanner in 72 patients with HypoPT and 25 patients with PHP and compared them with findings in 61 controls. LLAC were found in only two (3%) of the controls. Compared to the controls, LLAC were significantly more prevalent in patients with HypoPT (N = 12, [17%], p < 0.01) and PHP (N = 4, [16%], p < 0.04). Compared to the patients without calcifications, patients with calcifications had higher plasma calcium levels and a lower eGFR, as well as they were older and more often males. Plasma phosphate levels and the calcium-phosphate product were not associated with LLAC. In conclusion, we found that HypoPT and PHP are associated with an increased prevalence of vascular calcifications.

甲状旁腺功能减退症 (HypoPT) 和假性甲状旁腺功能减退症 (PHP) 分别是钙和磷酸盐稳态异常以及 PTH 水平低和高的疾病。据推测，这可能导致血管钙化，从而也可能导致心血管疾病。本研究的目的是评估 HypoPT 或 PHP 患者的小腿动脉钙化 (LLAC)。使用横断面设计，我们使用高分辨率外周定量计算机断层扫描 (HR-pQCT) 扫描仪测量了 72 名 HypoPT 患者和 25 名 PHP 患者的 LLAC，并将其与 61 名对照的结果进行了比较。LLAC 仅在两个 (3%) 对照中发现。与对照组相比，LLAC 在 HypoPT 患者中更为普遍（N  = 12，[17%]，p < 0.01) 和 PHP ( N  = 4, [16%], p  < 0.04)。与没有钙化的患者相比，有钙化的患者血浆钙水平较高，eGFR 较低，而且年龄较大且男性较多。血浆磷酸盐水平和磷酸钙产物与 LLAC 无关。总之，我们发现 HypoPT 和 PHP 与血管钙化的患病率增加有关。