miRNAs are well known to be gene repressors. A newly identified class of miRNAs termed nuclear activating miRNAs (NamiRNAs), transcribed from miRNA loci that exhibit enhancer features, promote gene expression via binding to the promoter and enhancer marker regions of the target genes. Meanwhile, activated enhancers produce endogenous non-coding RNAs (named enhancer RNAs, eRNAs) to activate gene expression. During chromatin looping, transcribed eRNAs interact with NamiRNAs through enhancer-promoter interaction to perform similar functions. Here, we review the functional differences and similarities between eRNAs and NamiRNAs in myogenesis and disease. We also propose models demonstrating their mutual mechanism and function. We conclude that eRNAs are active molecules, transcriptional regulators, and partners of NamiRNAs, rather than mere RNAs produced during enhancer activation.

中文翻译：

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增强子 RNA：NamiRNAs 在肌生成中的转录调节因子和同事

众所周知，miRNA 是基因阻遏物。一类新发现的 miRNA 称为核激活 miRNA (NamiRNA)，从表现出增强子特征的 miRNA 基因座转录而来，通过与靶基因的启动子和增强子标记区域结合来促进基因表达。同时，激活的增强子会产生内源性非编码 RNA（称为增强子 RNA，eRNA）以激活基因表达。在染色质循环过程中，转录的 eRNA 通过增强子-启动子相互作用与 NamiRNA 相互作用以执行类似的功能。在这里，我们回顾了 eRNA 和 NamiRNA 在肌生成和疾病中的功能差异和相似之处。我们还提出了展示它们相互机制和功能的模型。我们得出结论，eRNAs 是活性分子、转录调节因子和 NamiRNAs 的伙伴，